Phenotypes Associated with This Genotype

Genotype
MGI:2655166

• Allelic Composition: Cdk5rap2^an/Cdk5rap2^an
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:208 , J:5439 )

• animals die a few days after birth (J:208)

• most die within a few days or weeks of birth, however a few reach adulthood (J:5439)

growth/size/body

decreased body size ( J:208 , J:5439 )

hematopoietic system

anemia ( J:208 )

• anemic at birth

macrocytic anemia ( J:5439 )

abnormal erythrocyte morphology ( J:5439 )

• mean potential life span of erythrocytes is reduced

abnormal erythropoiesis ( J:5439 )

• erythropoiesis is decreased in the liver

• complete regression of hepatic hemopoiesis occurs at about 4 days after birth compared to 10 days in controls

anisocytosis ( J:5439 )

macrocytosis ( J:5439 )

• seen at birth

decreased leukocyte cell number ( J:5439 )

reticulocytopenia ( J:5439 )

immune system

decreased leukocyte cell number ( J:5439 )

reproductive system

decreased germ cell number ( J:15165 )

• reduced number of germ cells starting at E12-E13

decreased oocyte number ( J:15165 )

♀

increased ovary adenoma incidence ( J:15165 )

• eventually ovaries become tubular adenomas

abnormal spermatogenesis ( J:22618 )

♂ • almost no spermatogenesis is seen in adult testes

reduced fertility ( J:5439 , J:22618 )

• survivors are almost completely sterile (J:22618)

neoplasm

increased ovary adenoma incidence ( J:15165 )

• eventually ovaries become tubular adenomas

vision/eye

eye opacity ( J:22618 )

• older survivors (beyond 6-8 months) frequently develop eye opacities

skeleton

kyphosis ( J:22618 )

• older survivors (6-8 months) become kyphotic

integument

premature hair loss ( J:22618 )

• older survivors (6-8 months) lose their hair completely

cellular

decreased germ cell number ( J:15165 )

• reduced number of germ cells starting at E12-E13

decreased oocyte number ( J:15165 )

♀

endocrine/exocrine glands

increased ovary adenoma incidence ( J:15165 )

• eventually ovaries become tubular adenomas