Analysis Tools
reproductive system
 N |
• females are fertile
|
 |
• 4-fold increase in the number of apoptotic cells in the seminiferous tubules at 6 weeks of age
• apoptotic cells are clustered and primarily localized in germ cell layers that contain primary spermatocytes
|
|
|
• spermatozoa appear almost immotile, with a few displaying sluggish progressive or nonprogressive motility
|
|
|
• marked but variable reduction in testis weight
|
|
|
• defect in the elongation and nuclear condensation stage of spermiogenesis with the shedding of immature germ cells
|
|
|
• epididymal sperm counts are less than 10% of the numbers found in control mice
|
|
|
• more than 90% of spermatozoa are morphologically abnormal
|
|
|
• deformation of the sperm midpiece
|
|
|
• at least 70% of spermatozoa exhibit an aberrant head morphology, in most cases combined with middle piece deformation
|
|
|
• increased apoptosis of primary spermatocytes
|
endocrine/exocrine glands
|
|
• marked but variable reduction in testis weight
|
cellular
|
|
• epididymal sperm counts are less than 10% of the numbers found in control mice
|
|
|
• more than 90% of spermatozoa are morphologically abnormal
|
|
|
• deformation of the sperm midpiece
|
|
|
• at least 70% of spermatozoa exhibit an aberrant head morphology, in most cases combined with middle piece deformation
|
|
|
• increased apoptosis of primary spermatocytes
|
|
|
• 4-fold increase in the number of apoptotic cells in the seminiferous tubules at 6 weeks of age
• apoptotic cells are clustered and primarily localized in germ cell layers that contain primary spermatocytes
|
|
|
• spermatozoa appear almost immotile, with a few displaying sluggish progressive or nonprogressive motility
|
