Phenotypes Associated with This Genotype

Genotype
MGI:2654126

• Allelic Composition: Ucp1^tm1Kz/Ucp1^tm1Kz
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased brown adipose tissue amount ( J:40053 )

• mass of brown fat was greater in homozygous mice than in controls; thought to be due to increased deposition of triglyceride

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:40053 )

• animals did not become obese on either a low-fat or a high-fat diet

• no changes were observed in the body mass, selected fat-pad mass or in total body triglyceride content

• normal food intake was observed

impaired adaptive thermogenesis ( J:40053 )

• increased sensitivity to cold temperatures; most homozygous mice could not sustain body temperature when exposed to cold

abnormal oxygen consumption ( J:40053 )

• reduced oxygen consumption compared to controls was observed after treatment with a beta3-adrenergic agonist; resting oxygen consuption levels were similar to controls

decreased oxygen consumption ( J:62312 )

• in CL316243-treated mice

abnormal physiological response to xenobiotic ( J:40053 )

• abnormal response to beta3-adrenergic stimulation by the CL 316,243 agonist

growth/size/body

decreased susceptibility to diet-induced obesity ( J:40053 )

• animals did not become obese on either a low-fat or a high-fat diet

• no changes were observed in the body mass, selected fat-pad mass or in total body triglyceride content

• normal food intake was observed