Phenotypes Associated with This Genotype

Genotype
MGI:2654061

• Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺; Rbpj^tm1Hon/Rbpj^tm1Hon
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:76240 )

• mutants show high sensitivity to the lethal effects of blood-borne Staphylococcus aureus infection

immune system

abnormal B cell differentiation ( J:76240 )

• affected differentiation of T2 B cells, indicated by a reduced population of marginal zone B (MZB) cells and an increased population of follicular B cells

decreased marginal zone B cell number ( J:76240 , J:121523 )

• loss of marginal zone B cells (J:76240)

• decreased numbers of marginal zone B cells (J:121523)

increased follicular B cell number ( J:76240 , J:121523 )

• increased numbers of follicular B cells in spleen (J:121523)

increased IgG3 level ( J:76240 )

• 3-fold increase in serum IgG3

increased susceptibility to bacterial infection ( J:76240 )

• increased mortality rate after blood-born bacterial infection

increased susceptibility to bacterial infection induced morbidity/mortality ( J:76240 )

• mutants show high sensitivity to the lethal effects of blood-borne Staphylococcus aureus infection

hematopoietic system

abnormal B cell differentiation ( J:76240 )

• affected differentiation of T2 B cells, indicated by a reduced population of marginal zone B (MZB) cells and an increased population of follicular B cells

decreased marginal zone B cell number ( J:76240 , J:121523 )

• loss of marginal zone B cells (J:76240)

• decreased numbers of marginal zone B cells (J:121523)

increased follicular B cell number ( J:76240 , J:121523 )

• increased numbers of follicular B cells in spleen (J:121523)

increased IgG3 level ( J:76240 )

• 3-fold increase in serum IgG3