Phenotypes Associated with This Genotype

Genotype
MGI:2653987

• Allelic Composition: Gria1^tm1Rlh/Gria1^tm1Rlh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal associative learning ( J:135196 )

• mice fail to increase pokes of their nose into the prefered nose port upon a conditioned auditory cue while wild-type mice given the same training significantly increase the number of nose pokes by 5-fold

• the discrimination ratio between the conditioned and unconditioned noseport fails to be significantly different from chance

• the deficit in discriminating responding to the auditor cue is evident at the beginning of the test (i.e. does not result from differences in extinction rates)

• mice have no defects in normal food responses or overall locomotor activity

abnormal long-term spatial reference memory ( J:82443 )

• mutants exhibit a selective impairment in the retention of new learning at delays longer than a few hours, however learning is normal in the standard water maze task

nervous system

reduced long-term potentiation ( J:82443 )

• LTP induced by theta burst stimulation is greatly reduced in adult, but not young, mutants

• LTP induced by a conventional 1 Hz protocol is absent in young (P21-P28) mutants

• LTP induced by pairing depolarizing current injection with low-frequency stimulation is severely reduced

absent long-term depression ( J:82443 )