Phenotypes Associated with This Genotype

Genotype
MGI:2653884

• Allelic Composition: Abl2^tm1Ajk/Abl2^tm1Ajk
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:51887 )

• pups weigh about 80% of wild-type at 3 weeks of age, however by 8 weeks of age, weight does not differ from wild-type

behavior/neurological

novel environmental response-related retropulsion ( J:51887 )

• at 5 weeks of age, some mutants show increased tendency for retropulsion (walking backward) when placed in an open test field, however they are as active as littermate controls

decreased aggression ( J:51887 )

• males display decreased aggression towards intruding mice

absent startle reflex ( J:51887 )

• most mutants are not startled by acoustic stimuli

decreased startle reflex ( J:51887 )

• the magnitude of the startle responses of the few mutants that respond to an acoustic stimuli is only about 30% of the magnitude of controls

• mutants respond only slightly less well than controls to tactile (air puff) startle stimuli

abnormal motor coordination/balance ( J:51887 )

• poor performance on rope climbing test

• however, mutants are not ataxic, do not exhibit altered gait, and they are able to remain upright when walking on a narrow suspended platform

impaired coordination ( J:51887 )

• mutants spend less time hanging from a wire bar cage lid than controls

reproductive system

reduced fertility ( J:51887 )

• mutants produce litters at a reduced frequency, however litter sizes are normal