Phenotypes Associated with This Genotype

Genotype
MGI:2653847

• Allelic Composition: Cd1^tm1Gru/Cd1^tm1Gru
• Genetic Background: involves: 129S2/SvPas * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to infection induced morbidity/mortality ( J:126220 )

• cumulative mortality 7 days after infection with Coxsackie virus is 25% as compared to 67% for controls

immune system

immune system phenotype ( J:47769 )

N • despite near absence of IL-4-secreting NK-like T cells in the thymus, homozygotes are able to mount a normal T_H2 response producing IgE levels comparable to those detected in control littermates after immunization with anti-IgD

myocarditis ( J:126220 )

• reduced incidence of myocarditis caused by Coxsackie virus infection

abnormal eosinophil cell number ( J:84720 )

• substantial reduction in airway eosinophilia in response to OVA challenge

decreased CD4-positive, alpha-beta T cell number ( J:126220 )

• decreased Interferon gamma positive CD4+ cells

absent NK T cells ( J:47769 )

• homozygotes show near absence of the NK-like thymocyte population that secretes large amounts of IL-4 immediately after T cell receptor ligation and is characterized as heat-stable antigen (HAS)^-/low, V_beta8^int CD44^high (the NK1.1 marker is not expressed in the 129 and BALB/c genetic background of homozygous mutant mice)

decreased interleukin-4 secretion ( J:47769 )

• in vivo, homozygotes fail to promptly produce IL-4 after intravenous injection with anti-CD3

• in contrast, the induction of IFN-gamma mRNA after T cell receptor ligation remains unaffected

decreased susceptibility to infection induced morbidity/mortality ( J:126220 )

• cumulative mortality 7 days after infection with Coxsackie virus is 25% as compared to 67% for controls

hematopoietic system

abnormal eosinophil cell number ( J:84720 )

• substantial reduction in airway eosinophilia in response to OVA challenge

decreased CD4-positive, alpha-beta T cell number ( J:126220 )

• decreased Interferon gamma positive CD4+ cells

absent NK T cells ( J:47769 )

• homozygotes show near absence of the NK-like thymocyte population that secretes large amounts of IL-4 immediately after T cell receptor ligation and is characterized as heat-stable antigen (HAS)^-/low, V_beta8^int CD44^high (the NK1.1 marker is not expressed in the 129 and BALB/c genetic background of homozygous mutant mice)

neoplasm

decreased metastatic potential ( J:118828 )

• metastasis to the lung is reduced as measured by iv injection of colon carcinoma cell line CT26

cardiovascular system

myocarditis ( J:126220 )

• reduced incidence of myocarditis caused by Coxsackie virus infection

respiratory system

abnormal airway responsiveness ( J:84720 )

• hyper-reactivity does not develop in response to OVA challenge