Phenotypes Associated with This Genotype

Genotype
MGI:2653660

• Allelic Composition: Rb1^tm2Brn/Rb1^tm2Brn; Tg(Rbp3-cre)1Brn/0
• Genetic Background: involves: 129 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pituitary adenohypophysis tumor incidence ( J:77982 )

• develop pituitary gland tumors that arise from the anterior lobe of the pituitary gland

• however, do not develop retinoblastomas or pineal gland tumors

increased pituitary melanotroph tumor incidence ( J:77982 )

• develop pituitary gland tumors that arise from the intermediate lobe of the pituitary gland

endocrine/exocrine glands

increased pituitary adenohypophysis tumor incidence ( J:77982 )

• develop pituitary gland tumors that arise from the anterior lobe of the pituitary gland

• however, do not develop retinoblastomas or pineal gland tumors

increased pituitary melanotroph tumor incidence ( J:77982 )

• develop pituitary gland tumors that arise from the intermediate lobe of the pituitary gland

vision/eye

vision/eye phenotype ( J:77982 )

N • retinas appear normal

nervous system

increased pituitary adenohypophysis tumor incidence ( J:77982 )

• develop pituitary gland tumors that arise from the anterior lobe of the pituitary gland

• however, do not develop retinoblastomas or pineal gland tumors

increased pituitary melanotroph tumor incidence ( J:77982 )

• develop pituitary gland tumors that arise from the intermediate lobe of the pituitary gland