Phenotypes Associated with This Genotype

Genotype
MGI:2653528

• Allelic Composition: Ikzf1^{tm1.1(Pax5)Mbu}/Ikzf1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:118111 )

• mice die between 2 and 4 months of age

hematopoietic system

enlarged thymus ( J:118111 )

thymus hypoplasia ( J:118111 )

• significantly reduced at 2 weeks relative to Igh^tm1(PAX5)Mbu homozygotes

increased T cell derived lymphoma incidence ( J:118111 )

enlarged spleen ( J:118111 )

abnormal erythropoiesis ( J:80815 )

• number of erythroid precursors in bone marrow decreases to 1/20 of control numbers by 8 weeks of age

abnormal B cell differentiation ( J:80815 )

increased pro-B cell number ( J:80815 )

• at 8 weeks, number of pro-B cells is still 3.5-fold greater than controls

decreased double-positive T cell number ( J:118111 )

• significantly reduced at 2 weeks relative to Igh^tm1(PAX5)Mbu homozygotes

increased B cell number ( J:80815 )

• at E18.5, there are ~7-fold more B lymphocytes than in controls

immune system

enlarged thymus ( J:118111 )

thymus hypoplasia ( J:118111 )

• significantly reduced at 2 weeks relative to Igh^tm1(PAX5)Mbu homozygotes

increased T cell derived lymphoma incidence ( J:118111 )

enlarged spleen ( J:118111 )

abnormal B cell differentiation ( J:80815 )

increased pro-B cell number ( J:80815 )

• at 8 weeks, number of pro-B cells is still 3.5-fold greater than controls

decreased double-positive T cell number ( J:118111 )

• significantly reduced at 2 weeks relative to Igh^tm1(PAX5)Mbu homozygotes

increased B cell number ( J:80815 )

• at E18.5, there are ~7-fold more B lymphocytes than in controls

enlarged lymph nodes ( J:118111 )

neoplasm

increased lymphoma incidence ( J:118111 )

• lymphoid organs show diffuse infiltration by diffuse lymphoblastic lymphoma

• extensive tumor infiltrates are found in other organs including heart, kidneys, lungs, liver, intestine and testis

increased T cell derived lymphoma incidence ( J:118111 )

endocrine/exocrine glands

enlarged thymus ( J:118111 )

thymus hypoplasia ( J:118111 )

• significantly reduced at 2 weeks relative to Igh^tm1(PAX5)Mbu homozygotes

increased T cell derived lymphoma incidence ( J:118111 )

growth/size/body

enlarged spleen ( J:118111 )