Analysis Tools
muscle
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• mutants exhibit a defect in muscle spindle differentiation in the dorsal root ganglion and motor neurons
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nervous system
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• selective absence of Schwann cells at E16.5 in adductor and gracilis muscles but not in other muscles
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• mutants exhibit a defect in muscle spindle differentiation in the dorsal root ganglion and motor neurons
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• parvalbumin+ proprioceptive afferents are present in E16.5 hindlimb muscles and initiate contact with individual myofibers, but they do not develop annulospiral branches around the myofibers
• parvalbumin+ proprioceptive terminals at muscle spindles remain primitive and unbranched at E18.5
• however, survival and initial differentiation of proprioceptive afferent sensory neurons is not impaired
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cellular
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• selective absence of Schwann cells at E16.5 in adductor and gracilis muscles but not in other muscles
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