Phenotypes for Trp53 Xrcc1 MGI:2653518 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Trp53^tm1Tyj/Trp53^tm1Tyj Xrcc1^tm1Rpe/Xrcc1^tm1Rpe
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (249 available)
Xrcc1^tm1Rpe mutation (1 available); any Xrcc1 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:54226 )

• death by E9.0 to E9.5, 12 to 24 hours after mice homozygous for Xpre1^tm1Rpe alone

embryo

embryonic growth arrest ( J:54226 )

• developmental arrest about 6 h after mice homozygous for Xpre1^tm1Rpe alone

• unlike mice homozygous for Xpre1^tm1Rpe alone, small amounts of mesoderm found

decreased embryo size ( J:54226 )

• but bigger than mice homozygous for Xpre1^tm1Rpe alone

growth/size/body

decreased embryo size ( J:54226 )

• but bigger than mice homozygous for Xpre1^tm1Rpe alone

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24