Phenotypes for Trp53 Xrcc1 MGI:2653518 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Trp53^tm1Tyj/Trp53^tm1Tyj Xrcc1^tm1Rpe/Xrcc1^tm1Rpe
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (237 available)
Xrcc1^tm1Rpe mutation (1 available); any Xrcc1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:54226 )

• death by E9.0 to E9.5, 12 to 24 hours after mice homozygous for Xpre1^tm1Rpe alone

embryo

embryonic growth arrest ( J:54226 )

• developmental arrest about 6 h after mice homozygous for Xpre1^tm1Rpe alone

• unlike mice homozygous for Xpre1^tm1Rpe alone, small amounts of mesoderm found

decreased embryo size ( J:54226 )

• but bigger than mice homozygous for Xpre1^tm1Rpe alone

growth/size/body

decreased embryo size ( J:54226 )

• but bigger than mice homozygous for Xpre1^tm1Rpe alone

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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