Mouse Genome Informatics
cx
    Cd40lgtm1Flv/Cd40lgtm1Flv
Tg(APPSWE)2576Kha/0

involves: 129S2/SvPas * C57BL/6 * SJL
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• no detectable plaques at 12 months of age compared to minimal levels in mice carrying the transgene alone
• 41-51% reduction in beta-amyloid at 16 months as compared to transgene controls
• reduced numbers of large and medium sized plaques in the neocortex and hippocampus
• beta-CTF is reduced relative to alpha-CTF
• microgliosis and astrocytosis reduced

homeostasis/metabolism
• no detectable plaques at 12 months of age compared to minimal levels in mice carrying the transgene alone
• 41-51% reduction in beta-amyloid at 16 months as compared to transgene controls
• reduced numbers of large and medium sized plaques in the neocortex and hippocampus
• beta-CTF is reduced relative to alpha-CTF

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Immunodeficiency with Hyper-IgM, Type 1; HIGM1 308230 J:80429