Phenotypes Associated with This Genotype

Genotype
MGI:2653196

• Allelic Composition: Cd40lg^tm1Flv/Cd40lg^tm1Flv; Tg(APPSWE)2576Kha/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:80429 )

♀ • no detectable plaques at 12 months of age compared to minimal levels in mice carrying the transgene alone

♀ • 41-51% reduction in beta-amyloid at 16 months as compared to transgene controls

♀ • reduced numbers of large and medium sized plaques in the neocortex and hippocampus

♀ • beta-CTF is reduced relative to alpha-CTF

gliosis ( J:80429 )

♀ • microgliosis and astrocytosis reduced

homeostasis/metabolism

amyloid beta deposits ( J:80429 )

♀ • no detectable plaques at 12 months of age compared to minimal levels in mice carrying the transgene alone

♀ • 41-51% reduction in beta-amyloid at 16 months as compared to transgene controls

♀ • reduced numbers of large and medium sized plaques in the neocortex and hippocampus

♀ • beta-CTF is reduced relative to alpha-CTF