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Phenotypes Associated with This Genotype
Genotype
MGI:2653196
Allelic
Composition
Cd40lgtm1Flv/Cd40lgtm1Flv
Tg(APPSWE)2576Kha/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lgtm1Flv mutation (1 available); any Cd40lg mutation (5 available)
Tg(APPSWE)2576Kha mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• no detectable plaques at 12 months of age compared to minimal levels in mice carrying the transgene alone
• 41-51% reduction in beta-amyloid at 16 months as compared to transgene controls
• reduced numbers of large and medium sized plaques in the neocortex and hippocampus
• beta-CTF is reduced relative to alpha-CTF
• microgliosis and astrocytosis reduced

homeostasis/metabolism
• no detectable plaques at 12 months of age compared to minimal levels in mice carrying the transgene alone
• 41-51% reduction in beta-amyloid at 16 months as compared to transgene controls
• reduced numbers of large and medium sized plaques in the neocortex and hippocampus
• beta-CTF is reduced relative to alpha-CTF

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Immunodeficiency with Hyper-IgM, Type 1; HIGM1 308230 J:80429


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory