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Phenotypes Associated with This Genotype
Genotype
MGI:2651647
Allelic
Composition
Ttntm1Her/Ttntm1Her
Tg(Ckmm-cre)5Khn/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ckmm-cre)5Khn mutation (4 available)
Ttntm1Her mutation (0 available); any Ttn mutation (879 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• death at about 5 wks of age

behavior/neurological

cardiovascular system
N
• the heart was reduced in size, but in proportion to reduced overall body size
• no pathology of the heart was reported

growth/size/body
• apparent at 3 wks of age

muscle
• disarrayed sarcomeres, observed in less than 50% of the area of the myocytes
• pale, widened M-lines, devoid of M-line bridges
• resulting in abnormal posture, gait, and blepharoptosis

vision/eye

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive limb-girdle muscular dystrophy type 2J DOID:0110283 OMIM:608807
J:81993


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory