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Phenotypes Associated with This Genotype
Genotype
MGI:2651618
Allelic
Composition
Itgb2tm2Bay/Itgb2tm2Bay
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb2tm2Bay mutation (3 available); any Itgb2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Facial and neck alopecia with ulcerative dermatitis and conjunctivitis of the eye in Itgb2tm2Bay/Itgb2tm2Bay mice

mortality/aging
• 10 - 40% of newborns died perinatally

immune system
• impaired neutrophil extravasation into the interstitial tissue
• stimulated neutrophils did not adhere to KLH-coated glass and observed no increase in cell adhesion and no decrease in the number of rolling cells upon fMLP stimulation
• modestly increased at 2.5-3 months of age
• serum total IgG, IgG1, IgG2a, and IgG2b concentrations were increased 10-15-fold at 2.5-3 months of age and IgG3 was modestly increased
• modestly increased at 2.5-3 months of age
• impaired T cell receptor (TCR)-dependent T cell proliferation
• serum level of IL-3 was increased by more than 20-fold
• serum level of IL-6 was increased by more than 20-fold
• neutrophils showed hypersegmentation and appendix formation of the nuclei
• increased leukocyte counts were largely due to elevated numbers of circulating neutrophils
• numbers of circulating leukocytes were increased up to six-fold
• due to a myeloid hyperplasia within the red pulp with weight increased by 2.5-fold
• reactive lymphadenopathy with an accumulation of plasma cells
• occasional inflammatory lesions were observed in the heart, salivary gland, liver, and intestine
• surviving mice developed extended facial and submandibular ulcerative dermatitis at about 3 months of age, with the dermal inflammatory cell infiltrate consisting of eosinophils, lymphocytes, histiocytes, and occasional perivascular plasma cells, and fewer neutrophils than expected
• increased susceptibility to death from S.pneumoniae infection, with no survival by day 10 of infection

vision/eye

hematopoietic system
• neutrophils showed hypersegmentation and appendix formation of the nuclei
• increased leukocyte counts were largely due to elevated numbers of circulating neutrophils
• numbers of circulating leukocytes were increased up to six-fold
• due to a myeloid hyperplasia within the red pulp with weight increased by 2.5-fold
• impaired neutrophil extravasation into the interstitial tissue
• stimulated neutrophils did not adhere to KLH-coated glass and observed no increase in cell adhesion and no decrease in the number of rolling cells upon fMLP stimulation
• modestly increased at 2.5-3 months of age
• serum total IgG, IgG1, IgG2a, and IgG2b concentrations were increased 10-15-fold at 2.5-3 months of age and IgG3 was modestly increased
• modestly increased at 2.5-3 months of age
• impaired T cell receptor (TCR)-dependent T cell proliferation

homeostasis/metabolism
• serum level of IL-3 was increased by more than 20-fold
• serum level of IL-6 was increased by more than 20-fold

integument
• surviving mice developed extended facial and submandibular ulcerative dermatitis at about 3 months of age, with the dermal inflammatory cell infiltrate consisting of eosinophils, lymphocytes, histiocytes, and occasional perivascular plasma cells, and fewer neutrophils than expected
• surviving mice developed facial alopecia
• surviving mice developed reddening of the skin

Mouse Models of Human Disease
OMIM ID Ref(s)
Leukocyte Adhesion Deficiency, Type I; LAD 116920 J:48542


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory