Analysis Tools
mortality/aging
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• 10 - 40% of newborns died perinatally
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immune system
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• impaired T cell receptor (TCR)-dependent T cell proliferation
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• impaired neutrophil extravasation into the interstitial tissue
• stimulated neutrophils did not adhere to KLH-coated glass and observed no increase in cell adhesion and no decrease in the number of rolling cells upon fMLP stimulation
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• modestly increased at 2.5-3 months of age
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• serum total IgG, IgG1, IgG2a, and IgG2b concentrations were increased 10-15-fold at 2.5-3 months of age and IgG3 was modestly increased
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• modestly increased at 2.5-3 months of age
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• serum level of IL-3 was increased by more than 20-fold
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• serum level of IL-6 was increased by more than 20-fold
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• neutrophils showed hypersegmentation and appendix formation of the nuclei
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• increased leukocyte counts were largely due to elevated numbers of circulating neutrophils
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• numbers of circulating leukocytes were increased up to six-fold
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• due to a myeloid hyperplasia within the red pulp with weight increased by 2.5-fold
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• reactive lymphadenopathy with an accumulation of plasma cells
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• occasional inflammatory lesions were observed in the heart, salivary gland, liver, and intestine
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dermatitis
(
J:48542
)
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• surviving mice developed extended facial and submandibular ulcerative dermatitis at about 3 months of age, with the dermal inflammatory cell infiltrate consisting of eosinophils, lymphocytes, histiocytes, and occasional perivascular plasma cells, and fewer neutrophils than expected
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• increased susceptibility to death from S.pneumoniae infection, with no survival by day 10 of infection
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vision/eye
hematopoietic system
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• due to a myeloid hyperplasia within the red pulp with weight increased by 2.5-fold
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• neutrophils showed hypersegmentation and appendix formation of the nuclei
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• increased leukocyte counts were largely due to elevated numbers of circulating neutrophils
|
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• numbers of circulating leukocytes were increased up to six-fold
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• impaired T cell receptor (TCR)-dependent T cell proliferation
|
|
• impaired neutrophil extravasation into the interstitial tissue
• stimulated neutrophils did not adhere to KLH-coated glass and observed no increase in cell adhesion and no decrease in the number of rolling cells upon fMLP stimulation
|
|
• modestly increased at 2.5-3 months of age
|
|
• serum total IgG, IgG1, IgG2a, and IgG2b concentrations were increased 10-15-fold at 2.5-3 months of age and IgG3 was modestly increased
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• modestly increased at 2.5-3 months of age
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homeostasis/metabolism
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• serum level of IL-3 was increased by more than 20-fold
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• serum level of IL-6 was increased by more than 20-fold
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integument
dermatitis
(
J:48542
)
|
• surviving mice developed extended facial and submandibular ulcerative dermatitis at about 3 months of age, with the dermal inflammatory cell infiltrate consisting of eosinophils, lymphocytes, histiocytes, and occasional perivascular plasma cells, and fewer neutrophils than expected
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reddish skin
(
J:48542
)
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• surviving mice developed reddening of the skin
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cellular
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• impaired T cell receptor (TCR)-dependent T cell proliferation
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growth/size/body
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• due to a myeloid hyperplasia within the red pulp with weight increased by 2.5-fold
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| leukocyte adhesion deficiency 1 | DOID:0110910 |
OMIM:116920 |
J:48542 | |
