Phenotypes for Pax2 Pax8 MGI:2651547 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Pax2^tm1Mbu/Pax2^tm1Mbu Pax8^tm1(cre)Mbu/Pax8^tm1(cre)Mbu
Genetic Background	C3.Cg-Pax2^tm1Mbu Pax8^tm1(cre)Mbu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax2^tm1Mbu mutation (0 available); any Pax2 mutation (47 available)
Pax8^tm1(cre)Mbu mutation (0 available); any Pax8 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal kidney development ( J:80208 )

• extensive apoptosis in pronephros at 25 somite stage

• double mutant embryos fail to form the pronephros or any later nephric structures

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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