Phenotypes Associated with This Genotype

Genotype
MGI:2651381

• Allelic Composition: Itgb2^tm1Bay/Itgb2^tm1Bay
• Genetic Background: involves: 129S7/SvEvBrd * PL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Clinical features and histopathology of psoriasiform skin disease in Itgb2^tm1Bay/Itgb2^tm1Bay mice

immune system

myeloid hyperplasia ( J:32126 )

• exhibited myeloid hyperplasia in the bone marrow

increased leukocyte cell number ( J:32126 )

• Background Sensitivity: numbers of white blood cells were increased to a higher extent than on a 129S7/SvEvBrd background

increased basophil cell number ( J:32126 )

increased eosinophil cell number ( J:32126 )

increased neutrophil cell number ( J:32126 )

increased lymphocyte cell number ( J:32126 )

increased T cell number ( J:109598 )

• number of CD4+ and CD8+ T cells is highly increased in the epidermis and dermis

increased T-helper 1 cell number ( J:109598 )

• increase in Th1-type cytokine-producing CD4+ T cells but not in Th2-type cytokine producing T cells

increased monocyte cell number ( J:32126 )

abnormal spleen morphology ( J:32126 )

• exhibited myeloid hyperplasia in the spleen

abnormal T cell activation ( J:109598 )

• mice show increased state of activation in CD4+ T cells

abnormal cytokine level ( J:109598 )

• increase in Th1 cytokines, IFN-gamma, IL-2, and IL-10, in T cells from skin lesion-draining lymph nodes

enlarged lymph nodes ( J:32126 )

• displayed reactive lymphadenopathy

increased interferon-gamma secretion ( J:109598 )

• CD90+ T cells release up to 40-fold higher concentrations of IFN-gamma when cultured with anti-CD3 and anti-CD28 antibodies

dermatitis ( J:32126 , J:109598 )

• developed a progressive dermatitis, characterized by erythema, alopecia, and scale and crust formation (J:32126)

• mice develop psoriasiform dermatitis (J:109598)

• depletion of CD4+ T cells, but not of CD8+ T cells, with depleting antibodies results in resolution of the psoriasiform dermatitis after 6 weeks of treatment (J:109598)

hematopoietic system

myeloid hyperplasia ( J:32126 )

• exhibited myeloid hyperplasia in the bone marrow

thrombocytosis ( J:32126 )

increased leukocyte cell number ( J:32126 )

• Background Sensitivity: numbers of white blood cells were increased to a higher extent than on a 129S7/SvEvBrd background

increased basophil cell number ( J:32126 )

increased eosinophil cell number ( J:32126 )

increased neutrophil cell number ( J:32126 )

increased lymphocyte cell number ( J:32126 )

increased T cell number ( J:109598 )

• number of CD4+ and CD8+ T cells is highly increased in the epidermis and dermis

increased T-helper 1 cell number ( J:109598 )

• increase in Th1-type cytokine-producing CD4+ T cells but not in Th2-type cytokine producing T cells

increased monocyte cell number ( J:32126 )

abnormal spleen morphology ( J:32126 )

• exhibited myeloid hyperplasia in the spleen

abnormal T cell activation ( J:109598 )

• mice show increased state of activation in CD4+ T cells

pigmentation

pigmentation phenotype ( J:32126 )

N • Background Sensitivity: associated phenotype appears on the PL/J background but not on a C57BL/6 or 129S7/SvEvBrd background

integument

integument phenotype ( J:32126 )

N • Background Sensitivity: associated phenotypes appear on the PL/J background but not on a C57BL/6 or 129S7/SvEvBrd background

dermatitis ( J:32126 , J:109598 )

• developed a progressive dermatitis, characterized by erythema, alopecia, and scale and crust formation (J:32126)

• mice develop psoriasiform dermatitis (J:109598)

• depletion of CD4+ T cells, but not of CD8+ T cells, with depleting antibodies results in resolution of the psoriasiform dermatitis after 6 weeks of treatment (J:109598)

alopecia ( J:32126 , J:109598 )

• progressively developed in the facial region and/or base of the tail (J:32126)

abnormal hair follicle dermal papilla morphology ( J:32126 )

• vessels within the dermal papillae were dilated

abnormal dermal layer morphology ( J:32126 )

• dermal collagen appeared disorganized

mixed cellular infiltration to dermis ( J:32126 )

• progressive dermatitis with a dermal infiltrate consisting of granulocytes, lymphocytes, histiocytes and scattered mast cells

abnormal epidermal layer morphology ( J:32126 )

• occasionally developed focal spongiosis and erosion of the epidermis

orthokeratosis ( J:32126 )

• skin exhibited orthohyperkeratosis

parakeratosis ( J:32126 )

epidermal hyperplasia ( J:32126 )

• irregular psoriasiform hyperplasia of the epidermis

reddish skin ( J:32126 )

• dermatitis was characterized by erythema

scaly skin ( J:32126 , J:109598 )

• severely affected mice developed scales and crusts in the dorsum of the trunk, the abdomen, and the neck (J:32126)

abnormal skin condition ( J:32126 )

psoriasis ( J:32126 , J:109598 )

• had irregular psoriasiform hyperplasia of the epidermis and subcorneal microabscesses (J:32126)

• mice develop psoriasiform dermatitis (J:109598)

homeostasis/metabolism

abnormal cytokine level ( J:109598 )

• increase in Th1 cytokines, IFN-gamma, IL-2, and IL-10, in T cells from skin lesion-draining lymph nodes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
psoriasis		DOID:8893	OMIM:PS177900	J:32126 , J:109598