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Phenotypes Associated with This Genotype
Genotype
MGI:2651381
Allelic
Composition
Itgb2tm1Bay/Itgb2tm1Bay
Genetic
Background
involves: 129S7/SvEvBrd * PL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb2tm1Bay mutation (1 available); any Itgb2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Clinical features and histopathology of psoriasiform skin disease in Itgb2tm1Bay/Itgb2tm1Bay mice

immune system
• exhibited myeloid hyperplasia in the bone marrow
• Background Sensitivity: numbers of white blood cells were increased to a higher extent than on a 129S7/SvEvBrd background
• number of CD4+ and CD8+ T cells is highly increased in the epidermis and dermis
• increase in Th1-type cytokine-producing CD4+ T cells but not in Th2-type cytokine producing T cells
• exhibited myeloid hyperplasia in the spleen
• mice show increased state of activation in CD4+ T cells
• increase in Th1 cytokines, IFN-gamma, IL-2, and IL-10, in T cells from skin lesion-draining lymph nodes
• displayed reactive lymphadenopathy
• CD90+ T cells release up to 40-fold higher concentrations of IFN-gamma when cultured with anti-CD3 and anti-CD28 antibodies
• developed a progressive dermatitis, characterized by erythema, alopecia, and scale and crust formation (J:32126)
• mice develop psoriasiform dermatitis (J:109598)
• depletion of CD4+ T cells, but not of CD8+ T cells, with depleting antibodies results in resolution of the psoriasiform dermatitis after 6 weeks of treatment (J:109598)

hematopoietic system
• exhibited myeloid hyperplasia in the bone marrow
• Background Sensitivity: numbers of white blood cells were increased to a higher extent than on a 129S7/SvEvBrd background
• number of CD4+ and CD8+ T cells is highly increased in the epidermis and dermis
• increase in Th1-type cytokine-producing CD4+ T cells but not in Th2-type cytokine producing T cells
• exhibited myeloid hyperplasia in the spleen
• mice show increased state of activation in CD4+ T cells

pigmentation
N
• Background Sensitivity: associated phenotype appears on the PL/J background but not on a C57BL/6 or 129S7/SvEvBrd background

integument
N
• Background Sensitivity: associated phenotypes appear on the PL/J background but not on a C57BL/6 or 129S7/SvEvBrd background
• developed a progressive dermatitis, characterized by erythema, alopecia, and scale and crust formation (J:32126)
• mice develop psoriasiform dermatitis (J:109598)
• depletion of CD4+ T cells, but not of CD8+ T cells, with depleting antibodies results in resolution of the psoriasiform dermatitis after 6 weeks of treatment (J:109598)
• progressively developed in the facial region and/or base of the tail (J:32126)
• vessels within the dermal papillae were dilated
• dermal collagen appeared disorganized
• progressive dermatitis with a dermal infiltrate consisting of granulocytes, lymphocytes, histiocytes and scattered mast cells
• occasionally developed focal spongiosis and erosion of the epidermis
• skin exhibited orthohyperkeratosis
• irregular psoriasiform hyperplasia of the epidermis
• dermatitis was characterized by erythema
• severely affected mice developed scales and crusts in the dorsum of the trunk, the abdomen, and the neck (J:32126)
• had irregular psoriasiform hyperplasia of the epidermis and subcorneal microabscesses (J:32126)
• mice develop psoriasiform dermatitis (J:109598)

homeostasis/metabolism
• increase in Th1 cytokines, IFN-gamma, IL-2, and IL-10, in T cells from skin lesion-draining lymph nodes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
psoriasis DOID:8893 OMIM:PS177900
J:32126 , J:109598


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory