Phenotypes Associated with This Genotype

Genotype
MGI:2450971

• Allelic Composition: Met^tm2Cpo/Met^tm4.1Cpo
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:81793 )

• impaired motor coordination in thin rod test

nervous system

abnormal neuron differentiation ( J:81793 )

• 25% decrease in granule cell proliferation

reduced cerebellar foliation ( J:81793 )

• reduced or absent fissures in declival sulcus and intercrural fissure

• reduction of secondary and posterolateral fissures

small cerebellum ( J:81793 )

• cerebellar weight reduced by 20%

cellular

abnormal neuron differentiation ( J:81793 )

• 25% decrease in granule cell proliferation