Phenotypes Associated with This Genotype

Genotype
MGI:2450873

• Allelic Composition: Ube2b^tm1Jhjh/Ube2b^tm1Jhjh
• Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB/N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal chiasmata formation ( J:81811 )

• increase in the number of chiasmata in diakinesis/metaphase I nuclei of spermatocytes indicating an increase in meiotic recombination

abnormal synaptonemal complex ( J:81811 )

♂ • synaptonemal complex structure is disturbed in pachytene and diplotene spermatocytes

♂ • during late pachytene, the synaptoneal complex is thinner and the average total length of the SC is increased compared to that in wild-type pachytene and early diplotene cells

increased male germ cell apoptosis ( J:81811 )

♂ • increased apoptosis of primary spermatocytes

abnormal spermatogenesis ( J:81811 )

♂ • spermatocyte development is impaired already during the fist wave of spermatogenesis

abnormal spermatocyte morphology ( J:81811 )

♂ • increased apoptosis of primary spermatocytes

♂ • synaptonemal complex structure and telomere localization are disturbed in pachytene and diplotene spermatocytes

♂ • during late pachytene, the synaptoneal complex is thinner and the average total length of the SC is increased compared to that in wild-type pachytene and early diplotene cells

abnormal male meiosis ( J:81811 )

♂ • increase in frequency of meiotic recombination during pachytene in spermatocytes as indicated by an increase in the number of MHL1 foci in pachytene spermatocytes and an increase in the number of chiasmata in diakinesis/metaphase I nuclei of spermatocytes

male infertility ( J:81811 )

♂

cellular

abnormal spermatocyte morphology ( J:81811 )

♂ • increased apoptosis of primary spermatocytes

♂ • synaptonemal complex structure and telomere localization are disturbed in pachytene and diplotene spermatocytes

♂ • during late pachytene, the synaptoneal complex is thinner and the average total length of the SC is increased compared to that in wild-type pachytene and early diplotene cells

abnormal telomere morphology ( J:81811 )

♂ • telomere localization is disturbed in pachytene and diplotene spermatocytes

abnormal chiasmata formation ( J:81811 )

• increase in the number of chiasmata in diakinesis/metaphase I nuclei of spermatocytes indicating an increase in meiotic recombination

abnormal male meiosis ( J:81811 )

♂ • increase in frequency of meiotic recombination during pachytene in spermatocytes as indicated by an increase in the number of MHL1 foci in pachytene spermatocytes and an increase in the number of chiasmata in diakinesis/metaphase I nuclei of spermatocytes

abnormal synaptonemal complex ( J:81811 )

♂ • synaptonemal complex structure is disturbed in pachytene and diplotene spermatocytes

♂ • during late pachytene, the synaptoneal complex is thinner and the average total length of the SC is increased compared to that in wild-type pachytene and early diplotene cells

increased male germ cell apoptosis ( J:81811 )

♂ • increased apoptosis of primary spermatocytes