Analysis Tools
craniofacial
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• molars show a subtle loss of surface contour, however do not exhibit any other abnormalities in the appendicular, axial, or craniofacial skeleton
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• at 2 months of age, mutant facies begin to look more triangular
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short snout
(
J:69141
)
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• apparent 2 months after birth
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reproductive system
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• few, if any, active sperm are detected in semen
• significant reduction of mature sperm in testicular sections
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• no vaginal plugs or pregnancies are observed following breeding of male homozygotes with fertile wild-type females
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respiratory system
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• lungs show distal air space distension at both 2 weeks and 2 months of age, indicating an emphysema-like appearance without inflammation or fibrosis
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skeleton
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• molars show a subtle loss of surface contour, however do not exhibit any other abnormalities in the appendicular, axial, or craniofacial skeleton
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• at 2 months of age, the xiphoid is significantly concave and mineralized
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integument
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• at 2 months of age, hair follicles look thinner
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• collagen fibrils in skin are abnormally curled and reduced in thickness by ~50% at 2 months of age
• however, no defects in the structure of cartilage or collagen fibrils of cartilage are observed, eventhough a portion of N-propeptides of type II procollagen was not cleaved
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• at 1-2 months of age, mutant skin feels thinner and softer and tears after handling; becomes more severe with age
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growth/size/body
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• molars show a subtle loss of surface contour, however do not exhibit any other abnormalities in the appendicular, axial, or craniofacial skeleton
|
|
• at 2 months of age, mutant facies begin to look more triangular
|
short snout
(
J:69141
)
|
• apparent 2 months after birth
|
cellular
|
|
• few, if any, active sperm are detected in semen
• significant reduction of mature sperm in testicular sections
|
