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Phenotypes Associated with This Genotype
Genotype
MGI:2450509
Allelic
Composition
Adamts1tm1Hku/Adamts1tm1Hku
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts1tm1Hku mutation (0 available); any Adamts1 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• reduced volume of epidymal fat

endocrine/exocrine glands
• cavities in the adrenal medulla
• decrease in amount of capillaries
• normal adrenal cortex
• normal levels of catecholamine metabolites in urine, indicating normal adrenal function

growth/size/body
• 30% reduction at 9 months of age
• cystic formations

homeostasis/metabolism
N
• normal serum cholesterol, glucose and cholesterol levels
• normal serum creatine levels
• normal blood urea nitrogen levels

renal/urinary system
• severely reduced corticomedullary tissue
• poorly developed or absent papillae
• poorly developed or absent papillae
• greatly enlargeed caliceal space, first evident at 1 wk and progressing afterward
• accumulation of collagen between epithelial and smooth muscle cell layers
• retraction of the ureteropelvic junction inside the hilium, which was surrounded by fibrous tissue
• obstruction of the ureteropelvic junction
• increased urine volumes on 0.7% and 8.0% NaCl diets

reproductive system
• cystic formations
• reduced number of implantations observed 10 dpc
• 13% of females became pregnant after plug formation; males were fertile

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
urinary tract obstruction DOID:5200 J:62260


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory