Phenotypes for Rad50 Trp53 MGI:2450431 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Rad50^tm2Jpt/Rad50^tm2Jpt Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50^tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (249 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:78820 )

• mean age of death is 4.5 months

neoplasm

increased T cell derived lymphoma incidence ( J:78820 )

immune system

immune system phenotype ( J:78820 )

N	• B cell numbers increased 5-20 fold compared to Rad50^tm2Jpt homozygous mice

increased T cell derived lymphoma incidence ( J:78820 )

reproductive system

abnormal testis morphology ( J:78820 )

• suppression of testicular apoptosis

• normal meiotic progression

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:78820 )

abnormal testis morphology ( J:78820 )

• suppression of testicular apoptosis

• normal meiotic progression

hematopoietic system

increased T cell derived lymphoma incidence ( J:78820 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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