Phenotypes Associated with This Genotype

Genotype
MGI:2449942

• Allelic Composition: Erbb2^{tm3(Erbb2)Mul}/Erbb2^{tm3(Erbb2)Mul}; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:81565 )

• early mortality is observed in severely affected mutants

behavior/neurological

impaired coordination ( J:81565 )

• loss of coordination

impaired limb coordination ( J:81565 )

abnormal posture ( J:81565 )

• progressive with age, animals rest on abdomen instead of limbs

abnormal limb posture ( J:81565 )

• mutants often maintain limbs in an abnormal posture, progressing from a flexor to an extensor posture

abnormal gait ( J:81565 )

• progressive with age

craniofacial

malocclusion ( J:81565 )

growth/size/body

malocclusion ( J:81565 )

cachexia ( J:81565 )

muscle

increased myoblast apoptosis ( J:81565 )

• an increase in apoptosis is observed in mutant myoblasts infected with adenoviral-cre (to completely obliterate expression) during induced differentiation

absent primary muscle spindle ( J:81565 )

absent secondary muscle spindle ( J:81565 )

impaired skeletal muscle regeneration ( J:81565 )

• 2 weeks after a muscle crush injury in the tibialis anterior, muscle fibers that have regenerated are not continuous and are interspersed with encapsulated cellular debris

skeleton

malocclusion ( J:81565 )

nervous system

absent primary muscle spindle ( J:81565 )

absent secondary muscle spindle ( J:81565 )

cellular

increased myoblast apoptosis ( J:81565 )

• an increase in apoptosis is observed in mutant myoblasts infected with adenoviral-cre (to completely obliterate expression) during induced differentiation