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Phenotypes Associated with This Genotype
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lgtm1Imx mutation (3 available); any Cd40lg mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• serum IgM and IgG3 levels are more or less normal at all ages
• failure to form germinal centers
• failure to form germinal centers in inguinal lymph nodes although primary follicle formation is normal
• about 1/3 that of controls while overall T and B cell numbers are normal
• undetectable
• unable to mount a secondary response to TNP-KLH antigen (T cell dependent)
• T cell independent responses are normal as is isotype switching for these antigens

hematopoietic system
• failure to form germinal centers
• undetectable

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Immunodeficiency with Hyper-IgM, Type 1; HIGM1 308230 J:21137

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory