Mouse Genome Informatics
ot
    Cd40lgtm1Imx/Y
involves: 129S2/SvPas * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• serum IgM and IgG3 levels are more or less normal at all ages
• failure to form germinal centers
• failure to form germinal centers in inguinal lymph nodes although primary follicle formation is normal
• about 1/3 that of controls while overall T and B cell numbers are normal
• undetectable
• unable to mount a secondary response to TNP-KLH antigen (T cell dependent)
• T cell independent responses are normal as is isotype switching for these antigens

hematopoietic system
• failure to form germinal centers
• undetectable

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Immunodeficiency with Hyper-IgM, Type 1; HIGM1 308230 J:21137