Mouse Genome Informatics
involves: 129S2/SvPas * C57BL/6
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• serum IgM and IgG3 levels are more or less normal at all ages (J:21137)
• failure to form germinal centers (J:21137)
• failure to form germinal centers in inguinal lymph nodes although primary follicle formation is normal (J:21137)
• about 1/3 that of controls while overall T and B cell numbers are normal (J:21137)
• undetectable (J:21137)
• unable to mount a secondary response to TNP-KLH antigen (T cell dependent) (J:21137)
• T cell independent responses are normal as is isotype switching for these antigens (J:21137)

hematopoietic system
• failure to form germinal centers (J:21137)
• undetectable (J:21137)

Mouse Models of Human Disease
NOT Immunodeficiency with Hyper-IgM, Type 1; HIGM1 308230 J:21137