Phenotypes Associated with This Genotype

Genotype
MGI:2449491

• Allelic Composition: Cd40lg^tm1Imx/Y
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:21137 )

♂N • serum IgM and IgG3 levels are more or less normal at all ages

abnormal immune system organ morphology ( J:21137 )

♂

absent spleen germinal center ( J:21137 )

♂ • failure to form germinal centers

abnormal lymph node morphology ( J:21137 )

♂

absent lymph node germinal center ( J:21137 )

♂ • failure to form germinal centers in inguinal lymph nodes although primary follicle formation is normal

lymph node hypoplasia ( J:21137 )

♂ • about 1/3 that of controls while overall T and B cell numbers are normal

abnormal immune system physiology ( J:21137 )

♂

abnormal class switch recombination ( J:21137 )

♂

decreased immunoglobulin level ( J:21137 )

♂

decreased IgA level ( J:21137 )

♂

decreased IgE level ( J:21137 )

♂ • undetectable

decreased IgG1 level ( J:21137 )

♂

decreased IgG2b level ( J:21137 )

♂

abnormal antigen presentation ( J:21137 )

♂ • unable to mount a secondary response to TNP-KLH antigen (T cell dependent)

♂ • T cell independent responses are normal as is isotype switching for these antigens

hematopoietic system

abnormal class switch recombination ( J:21137 )

♂

absent spleen germinal center ( J:21137 )

♂ • failure to form germinal centers

decreased immunoglobulin level ( J:21137 )

♂

decreased IgA level ( J:21137 )

♂

decreased IgE level ( J:21137 )

♂ • undetectable

decreased IgG1 level ( J:21137 )

♂

decreased IgG2b level ( J:21137 )

♂