Phenotypes Associated with This Genotype

Genotype
MGI:2449029

• Allelic Composition: Dll1^tm1Gos/Dll1^tm1Gos
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:39633 )

• death around E12

embryo

abnormal direction of embryo turning ( J:80018 )

• tail rotation to the left in about 48% of embryos but random relative to heart looping

abnormal paraxial mesoderm morphology ( J:39633 )

• severe patterning defects in paraxial mesoderm

enlarged floor plate ( J:80018 )

• enlarged floor plate between E8.5 and E10.5

abnormal notochord morphology ( J:80018 )

• some regions appear as a sheet of cells associated with the dorsal primitive gut endoderm

• reduced number of notochord cells

abnormal primitive node morphology ( J:80018 )

• rupture of surface, bulging of cells

• by late headfold stage, abnormal cell morphology disrupts symmetry

absent embryonic cilia ( J:80018 )

• loss of monociliated cells

abnormal somite development ( J:39633 )

abnormal somite border morphology ( J:39633 )

• myoblasts span segment (somite) borders, indicating that borders are not maintained

abnormal somite shape ( J:39633 )

• irregularly shaped segments in the trunk

• distinct dermatomes present at E10.5 but segmental arrangement of myotome and sclerotome cells is disturbed

• myoblasts sometimes span space between adjacent segments

incomplete somite formation ( J:39633 )

• absence of segments in tail bud

• caudal sclerotome forms a uniform, loose, non segmental mass

nervous system

abnormal neuron differentiation ( J:39633 )

• excessive neuronal differentiation in CNS

enlarged floor plate ( J:80018 )

• enlarged floor plate between E8.5 and E10.5

abnormal brain development ( J:39633 )

• hyperplastic CNS

abnormal somatic nervous system morphology ( J:39633 )

fused dorsal root ganglion ( J:39633 )

abnormal spinal nerve morphology ( J:39633 )

• wide

• irregularly spaced

cardiovascular system

abnormal direction of heart looping ( J:80018 )

• heart looping to the left in about 50% of embryos

• looping is sometimes incomplete at E8.5-9.5

hemorrhage ( J:39633 )

• severely hemorrhagic after E10

endocrine/exocrine glands

abnormal pancreas development ( J:57072 )

• pancreatic bud decreased in size

• composed primarily of endocrine cells

cellular

absent embryonic cilia ( J:80018 )

• loss of monociliated cells

abnormal neuron differentiation ( J:39633 )

• excessive neuronal differentiation in CNS