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Phenotypes Associated with This Genotype
Genotype
MGI:2448446
Allelic
Composition
Spta1sph-ha/Spta1sph-ha
Genetic
Background
involves: DBA/1J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spta1sph-ha mutation (2 available); any Spta1 mutation (64 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• many animals die within a few days of birth (J:24729)
• Background Sensitivity: most homozygotes die within the first week of life, but some survive to adulthood (J:24829)
• Background Sensitivity: a small percentage of homozygotes die in utero

pigmentation

hematopoietic system
• severe neonatal hypochromic microcytic anemia
• red blood cells are bizzare in shape and staining capacity
• newborns have a mean hematocrit of 26.4 compared with 38.8 in controls and adults have a mean hematocrit of 29.1 compared with 48.7 in controls
• newborns and adults have less than half the normal hemoglobin concentration
• significantly reduced in both newborn homozygotes and adults
• reticulocytes synthesize 6-fold and initially bind 5-fold greater than normal amounts of newly synthesized alpha spectrin, yet accumulate very little in the membrane skeleton

reproductive system

cardiovascular system

immune system

liver/biliary system

skeleton
• bone marrow is hyperplastic

integument


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory