Phenotypes Associated with This Genotype

Genotype
MGI:2447790

• Allelic Composition: Adcyap1r1^tm1Bbt/Adcyap1r1^tm1Bbt
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:62115 )

• 60% loss of pups after birth until 4 weeks postnatal, no loss thereafter

behavior/neurological

shortened circadian behavior period ( J:70076 )

• under constant darkness

delayed circadian behavior phase ( J:70076 )

• longer phase delay in locomotor activity after light pulse in early evening vs. wild-type

growth/size/body

decreased body weight ( J:62115 )

• adult females had weak, but significant decreased body weight vs. wild-type littermates

homeostasis/metabolism

decreased circulating insulin level ( J:62115 )

• in glucose tolerance tests

increased circulating insulin level ( J:62115 )

• mild, in fed state

impaired glucose tolerance ( J:62115 )

• decreased glucose clearance in glucose tolerance tests

immune system

increased susceptibility to bacterial infection ( J:73990 )

• increased mortality in LPS-induced endotoxemia

reproductive system

prolonged diestrus ( J:105125 )

♀ • a longer and irregular diestrus was observed

prolonged estrous cycle ( J:105125 )

♀ • the oestrus cycle lasted more than 4 days

reduced female fertility ( J:105125 )

♀ • pairings produced one-third the number of litters produced by wildtype matings