Phenotypes Associated with This Genotype

Genotype
MGI:2447785

• Allelic Composition: Tsg101^tm1Kuw/Tsg101^tm1Kuw; Tg(Wap-cre)11738Mam/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

neoplasm ( J:80891 )

N • mice up to 24 months of age did not develop any mammary gland lesions

endocrine/exocrine glands

abnormal mammary gland development ( J:80891 )

♀ • severe inhibition of normal mammary gland development

abnormal mammary gland growth during lactation ( J:80891 )

♀ • alveolar development is severely impaired

♀ • mutants unable to initiate lactation exhibit alveolar compartment regression after several days

abnormal lactation ( J:80891 )

♀ • 60% of mice were completely unable to lactate after their first pregnancy; however, a small number of mice were able to establish lactation in their second or third pregnancies

integument

abnormal mammary gland development ( J:80891 )

♀ • severe inhibition of normal mammary gland development

abnormal mammary gland growth during lactation ( J:80891 )

♀ • alveolar development is severely impaired

♀ • mutants unable to initiate lactation exhibit alveolar compartment regression after several days

abnormal lactation ( J:80891 )

♀ • 60% of mice were completely unable to lactate after their first pregnancy; however, a small number of mice were able to establish lactation in their second or third pregnancies