Phenotypes Associated with This Genotype

Genotype
MGI:2387932

• Allelic Composition: Kif1b^tm1Noh/Kif1b^tm1Noh
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:69772 )

• animals died within 30 minutes of birth

behavior/neurological

unresponsive to tactile stimuli ( J:69772 )

• absent response in tail pinch and neck pinch tests

respiratory system

respiratory failure ( J:69772 )

• animals did not breathe, but lung structure and intercostal muscles appeared normal

skeleton

lordosis ( J:69772 )

• with dropping forelimbs

nervous system

decreased brain size ( J:69772 )

• small brain size; 10% smaller than normal

abnormal brain commissure morphology ( J:69772 )

• abnormal commissural fibers

abnormal brainstem morphology ( J:69772 )

• abnormal brain stem nuclei

abnormal hippocampus morphology ( J:69772 )

• hypocellularity and organization anomalies

decreased neuron number ( J:69772 )

• reduced number of neurons; less than 25% of controls; noted especially in the dorsal and ventral medullary reticular nuclei

abnormal synaptic vesicle number ( J:69772 )

• nerve terminals in the anterior horn areas of the spinal cord have reduced density of synaptic vesicles

abnormal spinal cord ventral horn morphology ( J:69772 )

• nerve terminals in the anterior horn areas of the spinal cord have reduced density of synaptic vesicles