Phenotypes Associated with This Genotype

Genotype
MGI:2387552

• Allelic Composition: Kit^W/Kit^W-v
• Genetic Background: involves: C57BL/6 * WB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

increased esophageal papilloma incidence ( J:6393 )

• observed papillomas in the lower end of the esophagus but not in the upper two-thirds of the esophagus

peptic ulcer ( J:6393 )

• 40% developed prepyloric ulcer, however no duodenal ulcers were found

neoplasm

increased papilloma incidence ( J:6393 )

• 40% developed forestomach papillomas

increased esophageal papilloma incidence ( J:6393 )

• observed papillomas in the lower end of the esophagus but not in the upper two-thirds of the esophagus

immune system

abnormal response to transplant ( J:6084 )

• after receiving splenocytes from Kitl/Kitl donors, 15 weeks later, mice exhibit significant increase in mast cell numbers in skin, stomach and mesentery

• after receiving skin grafts from Kitl/Kitl donors, no increase in mast cell number in skin is seen, compared to increase observed in reciprocal transplant