Phenotypes Associated with This Genotype

Genotype
MGI:2183820

• Allelic Composition: Vegfa^tm2Gne/Vegfa^tm2Gne; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129/Sv * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:52793 )

• 38% mortality at day 7 after birth when cre expression is induced with IFN-alpha at days 3, 5, and 7 postnatally

growth/size/body

decreased body size ( J:52793 )

• seen when Cre expression is induced by IFN-alpha at birth

postnatal growth retardation ( J:52793 )

• 52% of mice that survive past P7 when Cre expression is induced with IFN-alpha at days 3,5, and 7 postnatally are growth retarded

• however, when IFN-alpha is administered to 6 and 10 week old mice (to induce Cre expression), there are no significant changes in body mass

liver/biliary system

abnormal liver development ( J:52793 )

• seen when Cre expression is induced with IFN-alpha at birth; hepatocytes of 14 day old mutants are small and rounded and the hepatic sinusoidal architecture remains immature, with persistence of twin cell hepatic plates

• many sinusoids contain prominent eosinophilic histiocytes

hematopoietic system

extramedullary hematopoiesis ( J:52793 )

• 14 day old mutants treated with IFN-alpha to induce Cre expression exhibit increased extramedullary hematopoiesis