mortality/aging
• no lethality before E18.5 and mice are born at the expected ratio
• half usually die within the first 48 hours of life
• most are usually dead around the end of the 2nd week of life
|
growth/size/body
• body size at birth is 90% of controls by weight
|
weight loss
(
J:16077
)
• rapid weight loss after the middle of the 2nd week of life
|
• weight gain in the first two weeks of life is slowed
• by the middle of the 2nd week, body weight is 72% norma
|
behavior/neurological
• reduced capacity to walk
|
nervous system
• shortened
|
• hindbrain segmentation is less obvious or non-existent at E8.5-E10.5
• length of the rhombencephalon between nerve IX and the trigeminal ganglion is reduced
|
• complete elimination of r3
|
• reduced development of r3
|
• probable elimination of r5
|
• reduced development of r5
• all motor neurons arising exclusively in r5 are lost
|
• r6 reduced at E9.5
|
• major components of myelin in Schwann cells associated with the sciatic nerve are reduced
• nucleus morphology is aberrant
• increased Schwann cell morphology but devoid of myelin
|
• facial/acoustic ganglia are almost fused with the trigeminal ganglion
• ganglia V, VII/VIII are juxtaposed but not fused
|
• nucleus for the abducens not detected
• abducens nerve not seen
|
• motor nucleus of the facial nerve is relatively normal but positioned slightly rostrally
(J:16077)
• in close proximity to the trigeminal nerve
(J:16077)
• motor roots exit brain separate from those of the trigeminal nerve but both enter the second branchial arch together
(J:39350)
• distribution of facial neurons overlap in r6 with those of the glossopharyngeal nerve
(J:39350)
|
• in close proximity to the vagus nerve
(J:16077)
• distribution of facial neurons overlap in r6 with those of the glossopharyngeal nerve
(J:39350)
|
• in close proximity to the facial nerve
(J:16077)
• trigeminal nuclei are normal until E15.5 then dramatically reduced at E16.5
(J:39350)
• presence of trigeminal nucleus is inconsistent at E17.5 and almost completely eliminated by E18.5
(J:39350)
• motor roots exit brain separate from those of the facial nerve but both enter the second branchial arch together
(J:39350)
|
• in close proximity to the glossopharyngeal nerve
|
• major components of myelin in Schwann cells associated with the sciatic nerve are reduced
|
skeleton
• deformed
|
• about 24% shorter 2 weeks after birth
|
short radius
(
J:30822
)
short femur
(
J:30822
)
short tibia
(
J:30822
)
• bones very porous although bones of the skull are less affected
|
• lack of contact between growth plate and osteoblasts
|
• compressed hypertrophic growth plate
• reduced number and length of calcified trabeculae
|
• skeleton deficient in calcium
|
vision/eye
• retarded
|
limbs/digits/tail
short radius
(
J:30822
)
short femur
(
J:30822
)
short tibia
(
J:30822
)
craniofacial
• deformed
|
embryo
• shortened
|
• hindbrain segmentation is less obvious or non-existent at E8.5-E10.5
• length of the rhombencephalon between nerve IX and the trigeminal ganglion is reduced
|
• complete elimination of r3
|
• reduced development of r3
|
• probable elimination of r5
|
• reduced development of r5
• all motor neurons arising exclusively in r5 are lost
|
• r6 reduced at E9.5
|