Egr2^tm1Pch
Targeted Allele Detail

Summary

• Symbol: Egr2^tm1Pch
• Name: early growth response 2; targeted mutation 1, Patrick Charnay
• MGI ID: MGI:1857507
• Synonyms: Krox20^-, Krox20^lacZ, Krox20-lacZ
• Gene: Egr2 Location: Chr10:67371305-67378018 bp, + strand Genetic Position: Chr10, 34.96 cM, cytoband B5
• Alliance: Egr2^tm1Pch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:16077
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: In-frame insertion of a lacZ gene and a neomycin cassette. This allele expresses a chimeric protein consisting of 128 N-terminal amino acids fused to the entire beta-galactosidase protein. This fusion does not contain the zinc finger domain and therefore does not have DNA binding activity. (J:16077)

Expression

In Mice Carrying this Mutation:	288 assay results
In Structures Affected by this Mutation:	26 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Egr2 Mutation: 31 strains or lines available

References

• Original: J:16077 Schneider-Maunoury S, et al., Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain. Cell. 1993 Dec 17;75(6):1199-214
• All: 31 reference(s)