Analysis Tools
immune system
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• B cell proliferation is more sensitive to anti-IgM than wild-type B cells
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• at 14 weeks of age
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• mice exhibit a decrease in conventional B cells due to increased higher turnover rates than in wild-type mice
• peripheral B cell numbers are reduced by 50% to 70% of wild-type
• B220loHSAhi B lymphocytes are decreased 2- to 5-fold in lymphoid compartments
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• at 14 weeks of age, splenomegaly is often accompanied by enlargments of the lymph nodes with lymphoblasts and plasma cells
• blast cells within the lymph node are activated and have a B1 identity
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• mice develop anti-dsDNA antibodies around 16 weeks of age unlike wild-type mice
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hematopoietic system
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• B cell proliferation is more sensitive to anti-IgM than wild-type B cells
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• at 14 weeks of age
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• mice exhibit a decrease in conventional B cells due to increased higher turnover rates than in wild-type mice
• peripheral B cell numbers are reduced by 50% to 70% of wild-type
• B220loHSAhi B lymphocytes are decreased 2- to 5-fold in lymphoid compartments
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growth/size/body
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• at 14 weeks of age
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cellular
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• B cell proliferation is more sensitive to anti-IgM than wild-type B cells
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