immune system
• spleen weights are between 195 ad 257 mg (0.8% to 1.1% of body weight) compared to wild-type spleens that weigh between 86 and 125 mg (0.35% to 0.6% of body weight)
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• some mice exhibit increased white blood cell (WBC) counts (11-29x103 WBC per mm3 compared to 3-7x103 WBC per mm3 in wild-type mice)
• small homogeneous lymphocytes accumulate in the periportal and perivascular regions of the liver and lung, respectively
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• unlike wild-type mice, the marginal zone is absent from the white pulp
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• the amount of white pulp is reduced, disorganized and lacked marginal zones
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• mice lack visible lymph nodes (popliteal, inguineal, para-aortic, axillary and cervical)
• however, 4 of 14 mice possess abnormal lymph node-like structures in the mesenteric fat
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• when exposed to HSV or KLH mice fail to produce antigen-specific antibodies
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• less than 20 ug/ul compared to 80-1668 ug/ml in wild-type mice
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• 20+/-6 mg/dl compared to 15+/-3 mg/dl in wild-type mice
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hematopoietic system
• spleen weights are between 195 ad 257 mg (0.8% to 1.1% of body weight) compared to wild-type spleens that weigh between 86 and 125 mg (0.35% to 0.6% of body weight)
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• some mice exhibit increased white blood cell (WBC) counts (11-29x103 WBC per mm3 compared to 3-7x103 WBC per mm3 in wild-type mice)
• small homogeneous lymphocytes accumulate in the periportal and perivascular regions of the liver and lung, respectively
|
• unlike wild-type mice, the marginal zone is absent from the white pulp
|
• the amount of white pulp is reduced, disorganized and lacked marginal zones
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• less than 20 ug/ul compared to 80-1668 ug/ml in wild-type mice
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• 20+/-6 mg/dl compared to 15+/-3 mg/dl in wild-type mice
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growth/size/body
• spleen weights are between 195 ad 257 mg (0.8% to 1.1% of body weight) compared to wild-type spleens that weigh between 86 and 125 mg (0.35% to 0.6% of body weight)
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