Ltatm1Tab
Targeted Allele Detail
|
Symbol: |
Ltatm1Tab |
Name: |
lymphotoxin A; targeted mutation 1, Theresa A Banks |
MGI ID: |
MGI:1860957 |
Synonyms: |
LT-alpha-, LTalpha- |
Gene: |
Lta Location: Chr17:35422141-35424327 bp, - strand Genetic Position: Chr17, 18.59 cM
|
Alliance: |
Ltatm1Tab page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:28061
|
Parent Cell Line: |
D3 (ES Cell)
|
Strain of Origin: |
129S2/SvPas
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: A neomycin resistance cassette replaced a portion of exon 2, all of exon 3, and a portion of exon 4 of the gene. Southern blots confirmed absence of both wild-type alleles in homozygous mutant mice. RT-PCR of Con A-stimulated splenocytes from homozygous mutant mice showed no detectable mRNA for the targeted gene.
(J:28061)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Lta Mutation: |
17 strains or lines available
|
|
Original: |
J:28061 Banks TA, et al., Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness. J Immunol. 1995 Aug 15;155(4):1685-93 |
All: |
15 reference(s) |
|