Phenotypes Associated with This Genotype

Genotype
MGI:2181876

hm1

• Allelic Composition: Ttc21b^aln/Ttc21b^aln
• Genetic Background: involves: A/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal craniofacial morphology ( J:75360 )

• mice are described as having craniofacial abnormalities

limbs/digits/tail

polydactyly ( J:75360 )

• preaxial polydactyly was reported

abnormal limb bone morphology ( J:75360 )

• severe defects in the length and shape of long bones

skeleton

abnormal limb bone morphology ( J:75360 )

• severe defects in the length and shape of long bones

rib fusion ( J:75360 )

• rib fusions were observed

truncated ribs ( J:75360 )

• rib truncations were observed

abnormal vertebrae morphology ( J:75360 )

• described as misaligned

nervous system

abnormal neural tube morphology ( J:75360 )

• mice are described as having neural tube defects

abnormal brain morphology ( J:75360 )

• described as disorganized brain architecture

absent olfactory bulb ( J:75360 )

embryo

abnormal neural tube morphology ( J:75360 )

• mice are described as having neural tube defects

renal/urinary system

polycystic kidney ( J:213263 )

• cystic dilations of glomeruli and surrounding tubules at E16.5 and P0

• renal tubular dilations originate in proximal tubules and ascending loops of Henle

growth/size/body

polycystic kidney ( J:213263 )

• cystic dilations of glomeruli and surrounding tubules at E16.5 and P0

• renal tubular dilations originate in proximal tubules and ascending loops of Henle