Mouse Genome Informatics
hm
    Klkl/Klkl
either: C.Cg-Klkl or (involves: C3H/J * C57BL/6J)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• average lifespan is 60.7 days with none surviving more than 100 days
• overall phenotype resembles changes seen in human aging

growth/size
• beginning around 3-4 weeks of age

respiratory system
• ectopic calcification of the alveolar cells
• however, arterial blood oxygen content is similar to controls

other phenotype
• ectopic calcification of the arterial walls, stomach, bronchial mucosa, alveolar cells, choroid plexus, skin, testes, and cardiac muscle

cardiovascular system
• progressive arteriosclerosis beginning around 4 weeks of age
• extensive medial calcification in the aorta
• mid-sized muscular arteries show medial calcification and intimal thickening
• small arteries in the kidney are extensively calcified
• circulation slows beginning around 3-4 weeks of age

skeleton
• decreased bone mineral density particularly in the mid portion of the long bones where density is reduced by about 20% compared to controls
• resembles human senile osteoporosis

behavior/neurological
• become inactive starting around 3-4 weeks of age
• mice older than 6 weeks of age display about a 50% reduction in spontaneous activit
• base length corrected mean stride lengths are reduced

reproductive system
(J:44109)
• extremely atrophic (J:44109)
• external female genitalia are atrophic (J:44109)
(J:44109)
• impaired maturation
(J:44109)
• fail to mature beyond the pachytene stage (J:44109)
• external male genitalia are atrophic (J:44109)
• males and females are unable to mate

nervous system
• luteinizing hormone and follicle stimulating hormone producing cells appear slightly atrophic
• growth hormone producing cells are smaller
• the number of secretory granules in growth hormone producing cells is reduced
• however, no other signs of brain atrophy or age-related changes in the brain are detected

endocrine/exocrine glands
• luteinizing hormone and follicle stimulating hormone producing cells appear slightly atrophic
• growth hormone producing cells are smaller
• the number of secretory granules in growth hormone producing cells is reduced
(J:44109)
• extremely atrophic (J:44109)
• decrease in pancreatic insulin level

immune system
• ratio of lymphocytes to leukocytes is decreased in the peripheral blood, 34.5 +/- 7.6% compared to 61.3 +/- 14.1% in controls
• thymus is barely detectable at 6-9 weeks of age but appears normal at early development stages

homeostasis/metabolism
• levels are 115.8 +/- 13.8 mg/dl compared to 231.5 +/- 22.6 mg/dl in controls
• slight increase in phosphorus level

adipose tissue

muscle
• calcification of the cardiac muscle

hematopoietic system
• ratio of lymphocytes to leukocytes is decreased in the peripheral blood, 34.5 +/- 7.6% compared to 61.3 +/- 14.1% in controls
• thymus is barely detectable at 6-9 weeks of age but appears normal at early development stages

integument
• overall atrophy resembling senile atrophoderma in humans

Mouse Models of Human Disease
OMIM IDRef(s)
Emphysema, Hereditary Pulmonary 130700 J:44109
Klotho; KL 604824 J:44109