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Phenotypes Associated with This Genotype
Genotype
MGI:2179821
Allelic
Composition
Il2rgtm1Cgn/Il2rgtm1Cgn
Genetic
Background
involves: 129 * CB20
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Cgn mutation (1 available); any Il2rg mutation (56 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 22-fold reduction in cellularity
• thymocytes do not activate in response to Con A
• in vitro class switch using LPS and IL-4 fail to generate more IgG1-positive cells
• 12-fold reduction in the spleen in 3-4 week old mice
• further loss occurs with age
• plasma cells in the gut are exceptionally rare
• 20-fold decrease in bone marrow though some cells are still present
• NK cells are not detected in the spleen
• 3 fold reduction of mature alphabeta T cells in the spleen
• reduction of T cells in lamina propia of gut is observed
• 12-fold reduction in number of T cells found in gut epithelium
• 8-fold reduction in cellularity
• no germinal centers are observed
• clusters of white pulp are diminished in number and size
• no IgE detected in the sera
• 3-fold reduction in sera levels
• no splenic NK killing activity is observed against a NK-sensitive target cell line
• splenic T cells do not proliferate in response to Con A
• Peyer's patchers are not observed

hematopoietic system
• thymocytes do not activate in response to Con A
• 22-fold reduction in cellularity
• in vitro class switch using LPS and IL-4 fail to generate more IgG1-positive cells
• 12-fold reduction in the spleen in 3-4 week old mice
• further loss occurs with age
• plasma cells in the gut are exceptionally rare
• 20-fold decrease in bone marrow though some cells are still present
• NK cells are not detected in the spleen
• 3 fold reduction of mature alphabeta T cells in the spleen
• reduction of T cells in lamina propia of gut is observed
• 12-fold reduction in number of T cells found in gut epithelium
• 8-fold reduction in cellularity
• no germinal centers are observed
• clusters of white pulp are diminished in number and size
• no IgE detected in the sera
• 3-fold reduction in sera levels
• no splenic NK killing activity is observed against a NK-sensitive target cell line
• splenic T cells do not proliferate in response to Con A

endocrine/exocrine glands
• 22-fold reduction in cellularity
• thymocytes do not activate in response to Con A


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory