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Phenotypes Associated with This Genotype
Genotype
MGI:2178096
Allelic
Composition
Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic
Background
either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd13tm1Ddu mutation (0 available); any Hoxd13 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• weight deficit (~10%) for first few months of life

reproductive system

embryo
• prechondrogenic patterns of cellular condensations of digits delayed

limbs/digits/tail
• digits III and IV are stiffer than wild-type
• reduction and deformation of phalangeal bones
• the second phalanges are either reduced in digits III and IV, or absent in digits II and V
• reduction in size of forelimb digits, especially digits II and IV, and the hindlimb digits, especially digits I, II, and V
• about 50% have an additional rudimentary digit posteriorly
• fusion of bones is observed at articulations
• the metacarpal and first phalange of digit II are often fused in a single bone rod
• the sesamold bones are sometimes partially fused to the phalangeal bone
• sesamold bones are either absent, reduced, or partially fused to the phalangeal bone
• the large bone (d4) of the carpus is split into two carpal bones
• reduction and deformation of metacarpal bones
• metatarsal I is largely deformed with an anterior protrusion
• shorter and thicker metatarsal bones

skeleton
• reduction and deformation of phalangeal bones
• the second phalanges are either reduced in digits III and IV, or absent in digits II and V
• sesamold bones are either absent, reduced, or partially fused to the phalangeal bone
• the large bone (d4) of the carpus is split into two carpal bones
• reduction and deformation of metacarpal bones
• metatarsal I is largely deformed with an anterior protrusion
• shorter and thicker metatarsal bones
• sacral vertebra 4 (S4) fused to sacral vertebra 3 (S3)
• delayed ossification of extremities

Mouse Models of Human Disease
OMIM ID Ref(s)
Synpolydactyly 1; SPD1 186000 J:15507


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory