Phenotypes for Hoxd12 Hoxd13 MGI:2178077 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hoxd12^tm2Ddu/Hoxd12⁺ Hoxd13^tm1Ddu/Hoxd13⁺
Genetic Background	either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd12^tm2Ddu mutation (1 available); any Hoxd12 mutation (14 available)
Hoxd13^tm1Ddu mutation (0 available); any Hoxd13 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal digit morphology ( J:36770 )

• postminimus in 80% of trans-heterozygous mice

brachyphalangia ( J:36770 )

• reduction in digit size of trans-heterozygous mice is most prominent in the second phalanges

brachydactyly ( J:36770 )

• trans-heterozygous mice exhibit a reduction of digits V and II in the forelimbs

skeleton

brachyphalangia ( J:36770 )

• reduction in digit size of trans-heterozygous mice is most prominent in the second phalanges

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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