Analysis Tools
mortality/aging
|
• mice that are born develop bleeding problems and die either within a few hours of birth or within 2 days of birth
|
|
• Background Sensitivity: mice on a background enriched for Black Swiss survive until days 5 or 7
|
|
• fewer than expected mice are alive at E10.5 through E11.5
|
digestive/alimentary system
embryo
|
• in some mice at E10.5
|
|
• some embryos at E10.5
|
|
• at E10.5, the degree of necrosis corresponds to severity of hemorrhaging
|
|
• at E9.5 to E12.5, some mice exhibit yolk sac vessels that are largely empty of blood and blood pools within the yolk sac cavity
• however, yolk sac blood vessels and membranes form normally
|
pale yolk sac
(
J:48273
)
|
• in some mice between E9.5 and E12.5
|
cardiovascular system
|
• in some mice between E9.5 and E11.5
|
hemorrhage
(
J:48273
)
|
• neonates exhibit massive bleeding into the abdominal cavity, as well as bleeding into the intestinal lumen
• at E10.5, mice exhibit bleeding in the yolk sac cavity, exocoelomic cavity and pericardial sac unlike wild-type mice
|
homeostasis/metabolism
|
• blood from E18.5 mice fails to clot
• however, addition of thrombin restores clotting
|
growth/size/body
|
• some embryos at E10.5
|
integument
