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Phenotypes Associated with This Genotype
Genotype
MGI:2177905
Allelic
Composition
Engtm1Dyl/Engtm1Dyl
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Engtm1Dyl mutation (0 available); any Eng mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no homozygotes survive beyond E11.5 (J:55403)
• no homozygotes survive beyond E11.5 (J:55403)

cardiovascular system
• atretic and disorganized (J:55403)
• atretic and disorganized (J:55403)
• intersomitic vessels are atretic and disorganized (J:55403)
• intersomitic vessels are atretic and disorganized (J:55403)
• homozygotes display disruption of vascular development between E9.5 and E10.5 (J:55403)
• homozygotes display disruption of vascular development between E9.5 and E10.5 (J:55403)
• disorganized and atretic (J:55403)
• disorganized and atretic (J:55403)
• homozygotes display defective endothelial remodeling between E9.5 and E10.5 (J:55403)
• homozygotes display defective endothelial remodeling between E9.5 and E10.5 (J:55403)
• at E10.5, homozygotes still display an immature perineural vascular plexus that fails to undergo endothelial remodeling (J:55403)
• at E10.5, homozygotes still display an immature perineural vascular plexus that fails to undergo endothelial remodeling (J:55403)
• at E10.5, homozygotes display multiple pockets of red blood cells on the surface of yolk sacs; no organized vitelline blood vessels are observed (J:55403)
• at E10.5, homozygotes display multiple pockets of red blood cells on the surface of yolk sacs; no organized vitelline blood vessels are observed (J:55403)
• as early as E9.5, homozygotes display poor vascular smooth muscle formation in embryonic tissues; a similar defect is noted at E8.5 in mutant yok sacs (J:55403)
• arrested vascular smooth muscle development in mutant yolk sacs precedes disruption of endothelial remodeling (J:55403)
• as early as E9.5, homozygotes display poor vascular smooth muscle formation in embryonic tissues; a similar defect is noted at E8.5 in mutant yok sacs (J:55403)
• arrested vascular smooth muscle development in mutant yolk sacs precedes disruption of endothelial remodeling (J:55403)
• at E10.5, the major vessels including the dorsal aortae, intersomitic vessels, branchial arches, and carotid arteries are atretic and disorganized (J:55403)
• at E10.5, the major vessels including the dorsal aortae, intersomitic vessels, branchial arches, and carotid arteries are atretic and disorganized (J:55403)
• at E10.5, the mutant heart tube continues to circulate blood but fails to undergo complete rotation (J:55403)
• at E10.5, the mutant heart tube continues to circulate blood but fails to undergo complete rotation (J:55403)
• at E10.5, homozygotes exhibit serosanguinous pericardial effusion (J:55403)
• at E10.5, homozygotes exhibit serosanguinous pericardial effusion (J:55403)

embryogenesis
• at E10.5, homozygotes display multiple pockets of red blood cells on the surface of yolk sacs; no organized vitelline blood vessels are observed (J:55403)
• at E10.5, homozygotes display multiple pockets of red blood cells on the surface of yolk sacs; no organized vitelline blood vessels are observed (J:55403)
• at E10.5, homozygotes are 3 times smaller than wild-type embryos (J:55403)
• at E10.5, homozygotes are 3 times smaller than wild-type embryos (J:55403)
• at E10.5, homozygotes contain only 18-22 somites while wild-type embryos contain 32-35 somites (J:55403)
• at E10.5, homozygotes contain only 18-22 somites while wild-type embryos contain 32-35 somites (J:55403)

growth/size/body
• at E10.5, homozygotes are 3 times smaller than wild-type embryos (J:55403)
• at E10.5, homozygotes are 3 times smaller than wild-type embryos (J:55403)

muscle
• as early as E9.5, homozygotes display poor vascular smooth muscle formation in embryonic tissues; a similar defect is noted at E8.5 in mutant yok sacs (J:55403)
• arrested vascular smooth muscle development in mutant yolk sacs precedes disruption of endothelial remodeling (J:55403)
• as early as E9.5, homozygotes display poor vascular smooth muscle formation in embryonic tissues; a similar defect is noted at E8.5 in mutant yok sacs (J:55403)
• arrested vascular smooth muscle development in mutant yolk sacs precedes disruption of endothelial remodeling (J:55403)

homeostasis/metabolism
• at E10.5, homozygotes exhibit serosanguinous pericardial effusion (J:55403)
• at E10.5, homozygotes exhibit serosanguinous pericardial effusion (J:55403)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory