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Phenotypes Associated with This Genotype
Genotype
MGI:2177829
Allelic
Composition
Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb3tm1Hyn mutation (5 available); any Itgb3 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Survival of Itgb3tm1Hyn/Itgb3tm1Hyn mice is compromised due to placental defects and hemorrhage

mortality/aging
• significant loss of homozygous pups up to three weeks of age due to hemorrhage (J:52262)
• significant loss of homozygous pups up to three weeks of age due to hemorrhage (J:52262)
• some homozygous animals suffered acute blood loss and crisis which lead to premature death (J:52262)
• some homozygous animals suffered acute blood loss and crisis which lead to premature death (J:52262)

cardiovascular system
• hypoxia-induced retinal neovascularization is significantly elevated as measure by numbers of vascular glomeruli at P17 (J:73752)
• hypoxia-induced retinal neovascularization is significantly elevated as measure by numbers of vascular glomeruli at P17 (J:73752)
• significantly elevated numbers of vessels per square millimeter of tumors, from injected cells, when compared with wild-type controls (J:73752)
• significantly elevated numbers of vessels per square millimeter of tumors, from injected cells, when compared with wild-type controls (J:73752)
• blood-vessel infiltration of matrigel implants impregnated with VEGF is significantly elevated (J:73752)
• in the presence of VEGF, the total number of vessel sprouts in aortic rings embedded in Matrigel is significantly higher compared to wild-type (J:73752)
• however, no increase in vessel density is seen on scruff skin (J:73752)
• blood-vessel infiltration of matrigel implants impregnated with VEGF is significantly elevated (J:73752)
• in the presence of VEGF, the total number of vessel sprouts in aortic rings embedded in Matrigel is significantly higher compared to wild-type (J:73752)
• however, no increase in vessel density is seen on scruff skin (J:73752)
• heart weight to body weight ratio is increased (J:119666)
• heart weight to body weight ratio is increased (J:119666)
• left ventricle weight to body weight ratio is increased by 4 weeks of age (J:119666)
• left ventricle weight to body weight ratio is increased by 4 weeks of age (J:119666)
• in 12-week-old spontaneous cardiac hypertrophy occurs in the absence of provocative stimulation (J:119666)
• in 12-week-old spontaneous cardiac hypertrophy occurs in the absence of provocative stimulation (J:119666)
• some homozygous embryos and newborn pups displayed hemorrhage in the skin, in petechiae and in purpura, and appeared anemic (J:52262)
• some homozygous embryos and newborn pups displayed hemorrhage in the skin, in petechiae and in purpura, and appeared anemic (J:52262)
• in some homozygous newborn pups which die before weaning and in many of the surviving homozygous adult mice (J:52262)
• in some homozygous newborn pups which die before weaning and in many of the surviving homozygous adult mice (J:52262)
(J:52262)
(J:52262)
• petechiae are observed around the mouth, indicating bleeding under the epidermis (J:52262)
• petechiae are observed around the mouth, indicating bleeding under the epidermis (J:52262)
• purpura are observed on the forelimb, indicating bleeding within the dermis (J:52262)
• purpura are observed on the forelimb, indicating bleeding within the dermis (J:52262)
• a significantly impaired contractile response to infusion of the inotropic agent Dobutamine (J:119666)
• a significantly impaired contractile response to infusion of the inotropic agent Dobutamine (J:119666)
• diastolic relaxation is impaired (dP/dt min and tau (Glantz) are significantly increased) (J:119666)
• diastolic relaxation is impaired (dP/dt min and tau (Glantz) are significantly increased) (J:119666)
• 12-week-old mice have reduced systolic function compared to wild-type littermates (J:119666)
• left ventricular peak systolic pressure is significantly decreased 7 days after pressure overload by transverse aortic constriction surgery (TAC) compared to wild-type (J:119666)
• left ventricular peak systolic pressure is decreased in 12-week-old mice (J:119666)
• 12-week-old mice have reduced systolic function compared to wild-type littermates (J:119666)
• left ventricular peak systolic pressure is significantly decreased 7 days after pressure overload by transverse aortic constriction surgery (TAC) compared to wild-type (J:119666)
• left ventricular peak systolic pressure is decreased in 12-week-old mice (J:119666)
• left ventricular end-diastolic pressure is significantly increased 7 days after pressure overload by transverse aortic constriction surgery (TAC) compared to wild-type (J:119666)
• the maximal change in pressure per unit time is significantly decreased 7 days after pressure overload by TAC surgery compared to wild-type (J:119666)
• minimal change in pressure per unit time is significantly increased 7 days after pressure overload by TAC surgery compared to wild-type (J:119666)
• left ventricular end-diastolic pressure is significantly increased 7 days after pressure overload by transverse aortic constriction surgery (TAC) compared to wild-type (J:119666)
• the maximal change in pressure per unit time is significantly decreased 7 days after pressure overload by TAC surgery compared to wild-type (J:119666)
• minimal change in pressure per unit time is significantly increased 7 days after pressure overload by TAC surgery compared to wild-type (J:119666)
• heart rate is significantly decreased 7 days after pressure overload by transverse aortic constriction surgery (TAC) compared to wild-type (J:119666)
• heart rate is significantly decreased 7 days after pressure overload by transverse aortic constriction surgery (TAC) compared to wild-type (J:119666)
• impairment of systolic and diastolic function after transverse aortic constriction is more severe than in wild-type controls (J:119666)
• cardiac tissue exhibits marked round cell infiltration 7 days after transverse aortic constriction surgery (J:119666)
• impairment of systolic and diastolic function after transverse aortic constriction is more severe than in wild-type controls (J:119666)
• cardiac tissue exhibits marked round cell infiltration 7 days after transverse aortic constriction surgery (J:119666)

hematopoietic system
• found in animals with splenomegaly (J:52262)
• found in animals with splenomegaly (J:52262)
• secondary to the excessive bleeding (J:52262)
• secondary to the excessive bleeding (J:52262)
• in 8-12-week-old mice (J:52262)
• in 8-12-week-old mice (J:52262)
• in 8-12-week-old mice (J:52262)
• in 8-12-week-old mice (J:52262)
• in 8-12-week-old mice (J:52262)
• in 8-12-week-old mice (J:52262)
• the monocyte count is dramatically increased in peripheral blood (J:119666)
• the monocyte count is dramatically increased in peripheral blood (J:119666)
• in 8-12-week-old mice (J:52262)
• in 8-12-week-old mice (J:52262)
• commonly associated with gastrointestinal bleeding (J:52262)
• commonly associated with gastrointestinal bleeding (J:52262)
• peritoneal macrophages express significantly more Tnf and Il1b (J:119666)
• peritoneal macrophages express significantly more Tnf and Il1b (J:119666)
• peritoneal macrophages migrate less efficiently (J:119666)
• peritoneal macrophages migrate less efficiently (J:119666)
• reduced formation of thrombi in Shwartzman-like reaction, an experimental model of hemorrhagic vasculitis induced by subcutaneous injection of LPS followed 24 h later by an injection of TNF-alpha in the same place (J:52262)
• platelet isolated from homozygous mice did not aggregate after ADP-induced activation in vitro (J:52262)
• platelet isolated from homozygous mice shows reduced clot retraction and greatly reduced fibrinogen uptake in vitro (J:52262)
• reduced formation of thrombi in Shwartzman-like reaction, an experimental model of hemorrhagic vasculitis induced by subcutaneous injection of LPS followed 24 h later by an injection of TNF-alpha in the same place (J:52262)
• platelet isolated from homozygous mice did not aggregate after ADP-induced activation in vitro (J:52262)
• platelet isolated from homozygous mice shows reduced clot retraction and greatly reduced fibrinogen uptake in vitro (J:52262)

reproductive system
(J:52262)
(J:52262)
• 9.5% of the embryos carried by homozygous mothers were found dead in utero at E14 and E17 (J:52262)
• 9.5% of the embryos carried by homozygous mothers were found dead in utero at E14 and E17 (J:52262)
• compromised survival of embryos in homozygous mother as a result of placental defects and intrauterine hemorrhage (J:52262)
• compromised survival of embryos in homozygous mother as a result of placental defects and intrauterine hemorrhage (J:52262)
• litter sizes of homozygous female were reduced significantly compared to wild-type (J:52262)
• litter sizes of homozygous female were reduced significantly compared to wild-type (J:52262)

embryogenesis
• within affected placentae of homozygous pregnant females, trophoblastic cells sometimes invaded the labyrinthine part of the placenta (J:52262)
• within affected placentae of homozygous pregnant females, trophoblastic cells sometimes invaded the labyrinthine part of the placenta (J:52262)
• thickened cell layers in the labyrinth layer in approximately 25% of placentae of homozygous pregnant females which were associated with dead embryos (J:52262)
• within affected placentae, the space between endothelial layers was reduced with evidence of increased necrosis (J:52262)
• thickened cell layers in the labyrinth layer in approximately 25% of placentae of homozygous pregnant females which were associated with dead embryos (J:52262)
• within affected placentae, the space between endothelial layers was reduced with evidence of increased necrosis (J:52262)

digestive/alimentary system
• in some homozygous newborn pups which die before weaning and in many of the surviving homozygous adult mice (J:52262)
• in some homozygous newborn pups which die before weaning and in many of the surviving homozygous adult mice (J:52262)

immune system
• the monocyte count is dramatically increased in peripheral blood (J:119666)
• the monocyte count is dramatically increased in peripheral blood (J:119666)
• commonly associated with gastrointestinal bleeding (J:52262)
• commonly associated with gastrointestinal bleeding (J:52262)
• peritoneal macrophages express significantly more Tnf and Il1b (J:119666)
• peritoneal macrophages express significantly more Tnf and Il1b (J:119666)
• peritoneal macrophages migrate less efficiently (J:119666)
• peritoneal macrophages migrate less efficiently (J:119666)
• cardiac tissue exhibits marked round cell infiltration 7 days after transverse aortic constriction surgery (J:119666)
• cardiac tissue exhibits marked round cell infiltration 7 days after transverse aortic constriction surgery (J:119666)
• ulcerative dermatitis in some homozygous animals undergoing crisis (J:52262)
• ulcerative dermatitis in some homozygous animals undergoing crisis (J:52262)

homeostasis/metabolism
• impairment of systolic and diastolic function after transverse aortic constriction is more severe than in wild-type controls (J:119666)
• cardiac tissue exhibits marked round cell infiltration 7 days after transverse aortic constriction surgery (J:119666)
• impairment of systolic and diastolic function after transverse aortic constriction is more severe than in wild-type controls (J:119666)
• cardiac tissue exhibits marked round cell infiltration 7 days after transverse aortic constriction surgery (J:119666)
• reduced formation of thrombi in Shwartzman-like reaction, an experimental model of hemorrhagic vasculitis induced by subcutaneous injection of LPS followed 24 h later by an injection of TNF-alpha in the same place (J:52262)
• platelet isolated from homozygous mice did not aggregate after ADP-induced activation in vitro (J:52262)
• platelet isolated from homozygous mice shows reduced clot retraction and greatly reduced fibrinogen uptake in vitro (J:52262)
• reduced formation of thrombi in Shwartzman-like reaction, an experimental model of hemorrhagic vasculitis induced by subcutaneous injection of LPS followed 24 h later by an injection of TNF-alpha in the same place (J:52262)
• platelet isolated from homozygous mice did not aggregate after ADP-induced activation in vitro (J:52262)
• platelet isolated from homozygous mice shows reduced clot retraction and greatly reduced fibrinogen uptake in vitro (J:52262)
• impaired hemostasis as evidenced by failure to arrest bleeding within 10 minutes following tail resection (J:52262)
• impaired hemostasis as evidenced by failure to arrest bleeding within 10 minutes following tail resection (J:52262)

renal/urinary system
• enlarged glomeruli and dilated and necrotic proximal tubules containing proteinaceous deposits are found secondary to the excessive bleeding (J:52262)
• enlarged glomeruli and dilated and necrotic proximal tubules containing proteinaceous deposits are found secondary to the excessive bleeding (J:52262)

liver/biliary system
• centrilobular necrosis of the liver are found secondary to the excessive bleeding (J:52262)
• centrilobular necrosis of the liver are found secondary to the excessive bleeding (J:52262)

vision/eye
N
• the patterns of neovascularization in P7 retinas isolated from wild-type or homozygous mutant mice showed no obvious differences (J:52262)
• the patterns of neovascularization in P7 retinas isolated from wild-type or homozygous mutant mice showed no obvious differences (J:52262)
• hypoxia-induced retinal neovascularization is significantly elevated as measure by numbers of vascular glomeruli at P17 (J:73752)
• hypoxia-induced retinal neovascularization is significantly elevated as measure by numbers of vascular glomeruli at P17 (J:73752)

tumorigenesis
• significantly elevated numbers of vessels per square millimeter of tumors, from injected cells, when compared with wild-type controls (J:73752)
• significantly elevated numbers of vessels per square millimeter of tumors, from injected cells, when compared with wild-type controls (J:73752)
• tumor size is enhanced significantly when injected with murine melanoma (B16F0) or lung carcinoma (CMT19T) cells (J:73752)
• tumor size is enhanced significantly when injected with murine melanoma (B16F0) or lung carcinoma (CMT19T) cells (J:73752)

cellular
• endothelial cells showed background levels of adhesion and no migration on vitronectin (J:73752)
• endothelial cells showed background levels of adhesion and no migration on vitronectin (J:73752)
• endothelial cells showed background levels of adhesion and no migration on vitronectin (J:73752)
• endothelial cells showed background levels of adhesion and no migration on vitronectin (J:73752)
• peritoneal macrophages migrate less efficiently (J:119666)
• peritoneal macrophages migrate less efficiently (J:119666)

muscle
• a significantly impaired contractile response to infusion of the inotropic agent Dobutamine (J:119666)
• a significantly impaired contractile response to infusion of the inotropic agent Dobutamine (J:119666)
• diastolic relaxation is impaired (dP/dt min and tau (Glantz) are significantly increased) (J:119666)
• diastolic relaxation is impaired (dP/dt min and tau (Glantz) are significantly increased) (J:119666)
• cardiac tissue exhibits marked round cell infiltration 7 days after transverse aortic constriction surgery (J:119666)
• cardiac tissue exhibits marked round cell infiltration 7 days after transverse aortic constriction surgery (J:119666)

integument
• petechiae are observed around the mouth, indicating bleeding under the epidermis (J:52262)
• petechiae are observed around the mouth, indicating bleeding under the epidermis (J:52262)
• purpura are observed on the forelimb, indicating bleeding within the dermis (J:52262)
• purpura are observed on the forelimb, indicating bleeding within the dermis (J:52262)
• ulcerative dermatitis in some homozygous animals undergoing crisis (J:52262)
• ulcerative dermatitis in some homozygous animals undergoing crisis (J:52262)

Mouse Models of Human Disease
OMIM ID Ref(s)
Bleeding Disorder, Platelet-Type, 16; BDPLT16 187800 J:52262


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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory