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Phenotypes Associated with This Genotype
Genotype
MGI:2177553
Allelic
Composition		 Gata1tm1Sho/Y
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Sho mutation (0 available); any Gata1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:36249 )
• male mice die between E10.5 and E11.5 due to severe anemia

hematopoietic system
abnormal erythropoiesis ( J:36249 )
• embryonic red blood cells are arrested at the proerythroblast stage and display occasional nuclear fragmentation
anemia ( J:36249 )
• no red blood is evident in the vasculature of otherwise normal appearing males at E9.5 and E10.5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory