Phenotypes Associated with This Genotype

Genotype
MGI:2177171

• Allelic Composition: Nodal^{TgR(MPSVNeo)413.dRob}/Nodal^{TgR(MPSVNeo)413.dRob}
• Genetic Background: 129S/SvEv-Nodal^{TgR(MPSVNeo)413.dRob}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:11389 )

• no live born homozygotes are detected

embryo

abnormal developmental patterning ( J:11389 )

• no formation of the embryonic axis, head-fold or somites

abnormal ectoderm development ( J:19211 )

• disorganized expansion of the embryonic ectoderm

abnormal mesoderm development ( J:3969 )

embryonic growth arrest ( J:19211 )

• development is arrested shortly after gastrulation

decreased embryo size ( J:11389 )

abnormal embryonic tissue morphology ( J:11389 , J:19211 )

• at E8.5, no fetal portion evident and at E9.5, embryo is highly disorganized (J:11389)

absent head fold ( J:11389 )

• no recognizable head fold formation

• at E8.5, the region normally occupied by early-head-fold-stage embryo contained randomly organized, highly folded multicellular tissue layers inserted into the ectoplacental cone

failure of primitive streak formation ( J:19211 )

• at an early gastrulation stage (E6.5) no evidence of the primitive streak

absent somites ( J:11389 )

abnormal extraembryonic tissue morphology ( J:19211 )

absent allantois ( J:11389 )

absent amnion ( J:11389 )

absent amniotic folds ( J:19211 )

abnormal extraembryonic ectoderm morphology ( J:19211 )

• the extra-embryonic ectoderm is not displaced proximally towards the ectoplacental cone by mesodermal cells

• disorganized expansion of the extra-embryonic ectoderm

• the proximal region of the embryo, comprising the extra-embryonic ectoderm, was no longer symmetrical but often exhibited an irregular twisted surface

abnormal parietal yolk sac morphology ( J:11389 )

• the correct number of parietal endoderm cells form, but the parietal yolk sac fails to expand correctly in the absence of a normal, rapidly growing, fetal portion

increased trophoblast giant cell number ( J:70738 )

small ectoplacental cone ( J:11389 )

• at E9.5, ectoplacental cone reduced in size

abnormal spongiotrophoblast layer morphology ( J:70738 )

• diploid spongiotrophoblasts are lost

absent placental labyrinth ( J:70738 )

absent visceral yolk sac ( J:11389 )

• absent visceral yolk sac at E8.5

abnormal extraembryonic mesoderm development ( J:19211 )

• deficient formation and/or movement of the extra-embryonic mesoderm

growth/size/body

decreased embryo size ( J:11389 )