Phenotypes Associated with This Genotype

Genotype
MGI:2177170

• Allelic Composition: Foxa2^tm1Jrt/Foxa2^tm1Jrt
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:19895 )

• die between E9.5 and E11.5

embryo

increased embryonic tissue cell apoptosis ( J:50810 )

• embryos exhibit an increase in overall level of cell death; cell death is higher in the region distal to the primitive streak than in the proximal region of the E6.5 embryo

abnormal developmental patterning ( J:19895 )

abnormal rostral-caudal axis patterning ( J:19895 )

• at E9.5 in less severely affected embryos the anterior structures are either misshapen or truncated

rostral body truncation ( J:19895 )

• at E9.5 in less severely affected embryos the anterior structures may be truncated

abnormal embryonic tissue morphology ( J:19895 )

• by E7.5 the embryonic tissues are reduced in size and abnormally shaped

• at E8.5 in severely affected embryos only a small structure links the posterior end of the embryo to the exocoelom and few embryonic tissues are recognizable

abnormal primitive endoderm morphology ( J:19895 )

• at E6.5 primitive endoderm cells accumulate at the distal tip of the embryo and these cells appear rough and dull

absent mesoderm ( J:50810 )

abnormal neural tube morphology ( J:19895 )

• in less severely affected embryos the anterior neural tube is abnormal

• dorso-ventral patterning of the neural tube is abnormal

absent floor plate ( J:19895 )

kinked neural tube ( J:19895 )

• in less severely affected embryos the posterior neural tube is kinked

absent notochord ( J:19895 )

absent primitive node ( J:19895 )

• at E7.5 no definitive node structure is detected

• cells expressing Gsc fail to migrate to the node

abnormal primitive streak formation ( J:19895 )

• at E7.5 only the region of the primitive streak closest to the embryonic extraembryonic tissue boundary is present

abnormal somite shape ( J:19895 )

• in less severely affected embryos the somites are irregularly shaped

decreased somite size ( J:19895 )

• in less severely affected embryos the somites are small

fused somites ( J:19895 )

• in less severely affected embryos the somites are often fused at the midline

embryonic-extraembryonic boundary constriction ( J:19895 )

• at E6.5 an abnormal constriction between the embryonic and extraembryonic tissue is seen

nervous system

abnormal neural tube morphology ( J:19895 )

• in less severely affected embryos the anterior neural tube is abnormal

• dorso-ventral patterning of the neural tube is abnormal

absent floor plate ( J:19895 )

kinked neural tube ( J:19895 )

• in less severely affected embryos the posterior neural tube is kinked

digestive/alimentary system

abnormal foregut morphology ( J:19895 )

• at E8.5 no signs of gut development are seen however by E9.5 a closed gut like structure is seen ventral to the spinal cord in the trunk region of some embryos

• at E9.5 in the anterior portion of the embryo cell expressing gut markers are found on the outside rather than the inside of the embryo suggesting failure of invagination

cellular

increased embryonic tissue cell apoptosis ( J:50810 )

• embryos exhibit an increase in overall level of cell death; cell death is higher in the region distal to the primitive streak than in the proximal region of the E6.5 embryo