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Phenotypes Associated with This Genotype
Genotype
MGI:2177047
Allelic
Composition		 Dmc1Mei11/Dmc1Mei11
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmc1Mei11 mutation (0 available); any Dmc1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased male germ cell number ( J:60747 )
• germ cells are absent in some sections of mutant seminiferous tubules
abnormal seminiferous tubule morphology ( J:60747 )
• relatively normal seminiferous tubule segments are juxtaposed with agametic tubule segments
abnormal spermiogenesis ( J:60747 )
• homozygotes display aberrant spermatid elongation
• flagellar development in spermatids is abnormal
male infertility ( J:60747 )
• male homozygotes fail to produce offspring

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:60747 )
• relatively normal seminiferous tubule segments are juxtaposed with agametic tubule segments

cellular
decreased male germ cell number ( J:60747 )
• germ cells are absent in some sections of mutant seminiferous tubules

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Sertoli cell-only syndrome DOID:0050457 J:60747

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory