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Phenotypes Associated with This Genotype
involves: 129P2/OlaHsd * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm2Gsc mutation (1 available); any Nr3c1 mutation (15 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• impaired stress response in Porsolt forced-swim test; mice show normal immobility scores in an initial test, but do not show an increased response in a 24-hour restest
• in a light-dark crossing task test, mice exhibit a reduced latentcy in entering an aversive bright compartment and spent more time there
• in a zero-maze test, mice demonstrated an increased number of entries into the averse open segment and spent more time there

• mice are 70+/-3% of the weight of control mice at 6-14 weeks of age
• mice are 82+/-0.4% of the length of control mice at 6-14 weeks of age

• bone density is reduced in the skull and pelvis bones

adipose tissue
• a displacement of fat tissue towards the head and neck from the rest of the body is apparent
• mice are not obese

endocrine/exocrine glands
• the morphology of the adrenal glands is similar to controls
• levels of adrenaline and noradrenaline in the adrenal glands is similar to controls

• morning levels of circulating glucocorticoids are elevated
• normal circadian rhythm is maintained
• plasma levels of ACTH are moderately reduced
• in the anterior pituitary, an increase in the level of ACTH and its transcript levels are seen

nervous system
• elevation of CRH peptide levels in the paraventricular nucleus of the hypothalamus (PVN)
• no change in the level of vasopression (AVP)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Cushing's syndrome DOID:12252 J:57315

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.10
The Jackson Laboratory