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Phenotypes Associated with This Genotype
Genotype
MGI:2176972
Allelic
Composition
Nr3c1tm2Gsc/Nr3c1tm2Gsc
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm2Gsc mutation (1 available); any Nr3c1 mutation (9 available)
Tg(Nes-cre)1Kln mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• impaired stress response in Porsolt forced-swim test; mice show normal immobility scores in an initial test, but do not show an increased response in a 24-hour restest (J:57315)
• impaired stress response in Porsolt forced-swim test; mice show normal immobility scores in an initial test, but do not show an increased response in a 24-hour restest (J:57315)
• in a light-dark crossing task test, mice exhibit a reduced latentcy in entering an aversive bright compartment and spent more time there (J:57315)
• in a zero-maze test, mice demonstrated an increased number of entries into the averse open segment and spent more time there (J:57315)
• in a light-dark crossing task test, mice exhibit a reduced latentcy in entering an aversive bright compartment and spent more time there (J:57315)
• in a zero-maze test, mice demonstrated an increased number of entries into the averse open segment and spent more time there (J:57315)

growth/size/body
• mice are 70+/-3% of the weight of control mice at 6-14 weeks of age (J:57315)
• mice are 70+/-3% of the weight of control mice at 6-14 weeks of age (J:57315)
• mice are 82+/-0.4% of the length of control mice at 6-14 weeks of age (J:57315)
• mice are 82+/-0.4% of the length of control mice at 6-14 weeks of age (J:57315)

skeleton
• bone density is reduced in the skull and pelvis bones (J:57315)
• bone density is reduced in the skull and pelvis bones (J:57315)

adipose tissue
• a displacement of fat tissue towards the head and neck from the rest of the body is apparent (J:57315)
• mice are not obese (J:57315)
• a displacement of fat tissue towards the head and neck from the rest of the body is apparent (J:57315)
• mice are not obese (J:57315)

endocrine/exocrine glands
N
• the morphology of the adrenal glands is similar to controls (J:57315)
• levels of adrenaline and noradrenaline in the adrenal glands is similar to controls (J:57315)
• the morphology of the adrenal glands is similar to controls (J:57315)
• levels of adrenaline and noradrenaline in the adrenal glands is similar to controls (J:57315)

homeostasis/metabolism
• morning levels of circulating glucocorticoids are elevated (J:57315)
• normal circadian rhythm is maintained (J:57315)
• morning levels of circulating glucocorticoids are elevated (J:57315)
• normal circadian rhythm is maintained (J:57315)
• plasma levels of ACTH are moderately reduced (J:57315)
• plasma levels of ACTH are moderately reduced (J:57315)
• in the anterior pituitary, an increase in the level of ACTH and its transcript levels are seen (J:57315)
• in the anterior pituitary, an increase in the level of ACTH and its transcript levels are seen (J:57315)

nervous system
• elevation of CRH peptide levels in the paraventricular nucleus of the hypothalamus (PVN) (J:57315)
• no change in the level of vasopression (AVP) (J:57315)
• elevation of CRH peptide levels in the paraventricular nucleus of the hypothalamus (PVN) (J:57315)
• no change in the level of vasopression (AVP) (J:57315)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory