Mouse Genome Informatics

involves: 129P2/OlaHsd * C57BL/6J * SJL
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
• impaired stress response in Porsolt forced-swim test; mice show normal immobility scores in an initial test, but do not show an increased response in a 24-hour restest
• in a light-dark crossing task test, mice exhibit a reduced latentcy in entering an aversive bright compartment and spent more time there
• in a zero-maze test, mice demonstrated an increased number of entries into the averse open segment and spent more time there

• mice are 70+/-3% of the weight of control mice at 6-14 weeks of age
• mice are 82+/-0.4% of the length of control mice at 6-14 weeks of age

• bone density is reduced in the skull and pelvis bones

adipose tissue
• a displacement of fat tissue towards the head and neck from the rest of the body is apparent
• mice are not obese

endocrine/exocrine glands
• the morphology of the adrenal glands is similar to controls (J:57315)
• levels of adrenaline and noradrenaline in the adrenal glands is similar to controls (J:57315)

• morning levels of circulating glucocorticoids are elevated
• normal circadian rhythm is maintained
• plasma levels of ACTH are moderately reduced
• in the anterior pituitary, an increase in the level of ACTH and its transcript levels are seen

nervous system
• elevation of CRH peptide levels in the paraventricular nucleus of the hypothalamus (PVN)
• no change in the level of vasopression (AVP)