Phenotypes Associated with This Genotype

Genotype
MGI:2176943

• Allelic Composition: Igf1^tm1Dlr/Igf1^tm1Dlr; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129/Sv * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:121798 )

N • after induction with PiPc, 6-mo-old mice exhibit no significant differences in serum and urine creatinine levels relative to control mice

decreased circulating insulin-like growth factor I level ( J:55718 , J:121798 )

• after induction with IFN at 24-28 days of age, mice exhibit a 75% reduction in serum IGF-I levels relative to control mice, still evident at 53 days of age (J:55718)

• after induction with PiPc at 4 weeks of age, mice exhibit a 80-85% reduction in serum IGF-I levels relative to control mice, still evident at 24 months of age (J:121798)

• renal IGF-II mRNA levels are reduced by 79%, suggesting that the effects of circulating IGF-I on kidney size may be mediated by renal IGF-II; however, no differences in serum IGF-II levels are observed at 9 months (J:121798)

increased circulating growth hormone level ( J:121798 )

• after induction with PiPc, mice exhibit compensatory increased circulating GH levels relative to control mice

increased urine potassium level ( J:121798 )

• after induction with PiPc, 6-mo-old mice exhibit increased 24-hr potassium excretion relative to control mice

increased urine sodium level ( J:121798 )

• after induction with PiPc, 6-mo-old mice exhibit increased 24-hr sodium excretion relative to control mice

growth/size/body

growth/size/body region phenotype ( J:55718 , J:121798 )

N • after induction with IFN at 24-28 days of age, mice exhibit normal postnatal body growth up to 53 days of age relative to control mice (J:55718)

N • after induction with PiPc at 4 weeks of age, mice exhibit no significant differences in body weight relative to control mice, as shown at 7 and 24 months of age (J:121798)

renal/urinary system

renal/urinary system phenotype ( J:121798 )

N • after induction with PiPc, 6-mo-old mice exhibit no significant differences in serum and urine creatinine levels, GFR, creatinine clearance, or 24-hr urine volume relative to control mice

N • no glomerulosclerosis, vascular defects, mesangial sclerosis, or cortical fibrosis is observed at 24 months of age

increased urine potassium level ( J:121798 )

• after induction with PiPc, 6-mo-old mice exhibit increased 24-hr potassium excretion relative to control mice

increased urine sodium level ( J:121798 )

• after induction with PiPc, 6-mo-old mice exhibit increased 24-hr sodium excretion relative to control mice

decreased kidney weight ( J:121798 )

• after induction with PiPc, absolute and relative kidney weight is reduced in 7- and 24-month-old mice relative to control mice

cardiovascular system

increased systemic arterial systolic blood pressure ( J:121798 )

• after induction with PiPc, 7-mo-old mice exhibit increased systolic blood pressure relative to control mice