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Phenotypes Associated with This Genotype
Genotype
MGI:2176529
Allelic
Composition
Ptpn11tm1Rbn/Ptpn11+
Genetic
Background
involves: 129 * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn11tm1Rbn mutation (0 available); any Ptpn11 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• heterozygotes show no significant differences in body weight, plasma insulin, glucose levels during fasting or after a glucose challenge, insulin-stimulated glucose uptake in soleus muscle and adipocytes, and insulin-inhibited lipolysis in adipocytes relative to wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Noonan Syndrome 1; NS1 163950 J:35137


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory